Results 91 to 100 of about 26,075,196 (289)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Unified first-principles framework for predicting radiative and non-radiative processes in color centers

npj Computational Materials
Uncovering promising spin-qubit candidates among a myriad of semiconductor point defects requires high-throughput screening based on first-principles calculations.
Sosuke Iwamoto, Masahiro Hara, Heiji Watanabe, Takuma Kobayashi   +3 more
doaj   +1 more source

Dissociative ionization cross-sections and the rate coefficients of H2S, OCS, LiH, and SiC

Astronomy & Astrophysics
Context. Electron-molecule and positron-molecule interactions play a major role in the interstellar medium. Although several inelastic channels have been studied in the literature, dissociative ionization studies of molecules are scarce. Aims.
Shanmugasundaram Suriyaprasanth, Dharmalingam Geetha, Graves Vincent, Gupta Dhanoj   +3 more
doaj   +1 more source

Radiative processes of small molecules

, 2019
Four types of astrochemically relevant radiative processes are studied: bound-bound, bound-free, free-bound and free-free. The former two together determine radiative lifetimes, which are calculated for the HeLi+ molecular ion. Free-bound processes, also
Šimsová, Martina
core  

The shortwave to longwave ratio in contrail radiative forcing as evident in two radiation schemes used for global GCMs [PDF]

, 2013
Contrail radiative forcing is difficult to obtain, even if contrail parameters like coverage, ice water content, crystal size etc. are known. Respective results as documented in literature hint to a substantial uncertainty.
Bock, Lisa, Ponater, Michael, Dietmüller, Simone, Frömming, Christine   +3 more
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Pushing Radiative Cooling Technology to Real Applications

Advances in Materials
Radiative cooling is achieved by controlling surface optical behavior toward solar and thermal radiation, offering promising solutions for mitigating global warming, promoting energy saving, and enhancing environmental protection.
Chongjia Lin, Ke-Qiao Li, Meng Li, Benjamin Dopphoopha, Jiongzhi Zheng, Jia-Zheng Wang, Shanshan Du, Yang Li, Bao-Lin Huang   +8 more
semanticscholar   +1 more source

Changing transport processes in the stratosphere by radiative heating of sulfate aerosols

, 2017
. The injection of sulfur dioxide (SO2) into the stratosphere to form an artificial stratospheric aerosol layer is discussed as an option for solar radiation management. Sulfate aerosol scatters solar radiation and absorbs infrared radiation, which warms
U. Niemeier, H. Schmidt
semanticscholar   +1 more source

Radiative forcing from aircraft NOx emissions: Mechanisms and seasonal dependence [PDF]

, 2004
A chemistry-climate model has been applied to study the radiative forcings generated by aircraft NOx emissions through changes in ozone and methane. Four numerical experiments, where an extra pulse of aircraft NOx was emitted into the model atmosphere ...
Stevenson, David S.; id_orcid, Derwent, Richard G., Doherty, Ruth M., Collins, William J., Johnson, Colin E., Sanderson, Michael G.   +5 more
core   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source