Results 71 to 80 of about 286,073 (277)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Radiative Processes in Cool Star Chromospheres

Physica Scripta, 1984
Observations made with the International Ultraviolet Explorer (IUE) satellite between 1200 A and 3000 A have shown that the spectra of giant and supergiant stars later than about K O are dominated by emission from neutral atoms and singly charged ions.
Jordan, C, Judge, P
openaire   +1 more source

Screw dislocation-induced growth spirals as emissive exciton localization centers in Al-rich AlGaN/AlN quantum wells

AIP Advances, 2015
Screw dislocations in Al-rich AlGaN/AlN quantum wells cause growth spirals with an enhanced Ga incorporation, which create potential minima. Although screw dislocations and their surrounding potential minima suggest non-radiative recombination processes ...
Mitsuru Funato, Ryan G. Banal, Yoichi Kawakami   +2 more
doaj   +1 more source

Nonthermal Emission from Star-Forming Galaxies

, 2013
The detections of high-energy gamma-ray emission from the nearby starburst galaxies M82 & NGC253, and other local group galaxies, broaden our knowledge of star-driven nonthermal processes and phenomena in non-AGN star-forming galaxies.
A.F.M. Moorwood, AL Roy, AR Bell, AS Wilson, BC Lacki, BC Lacki, BD Fields, C Ferrari, CL Carilli, DF Torres, DF Torres, DK Strickland, DK Strickland, DP Cox, E Domingo-Santamaría, ER Seaquist, F Mannucci, FS Tabatabaei, FS Tabatabaei, FW Stecker, G Helou, GE Romero, H Kühr, H.W.W. Spoon, I Lerche, I.V Moskalenko, I.V Moskalenko, J.-P. Lenain, JC Higdon, K Wilke, L Spinoglio, LJ Kewley, M Elmouttie, M Persic, M Persic, M Sasaki, MD Weinberg, O Goldshmidt, P Corral, R Beck, R Diehl, R Enomoto, R Schlickeiser, RA Chevalier, RC Kennicutt Jr, RF Haynes, RJ Protheroe, RM Baltrusaitis, S Bergh van den, SD Points, SE Woosley, SJ Petuchowski, T.A.D. Paglione, TA Thompson, U Klein, V Heesen, V Pavlidou, V Pavlidou, VN Zirakashvili, W Tucker, WR Webber, Y Rephaeli, Y Rephaeli, Y Rephaeli, Y Rephaeli, Y Rephaeli   +65 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Radiative corrections in processes at the SSC

, 1992
We discuss radiative corrections for interactions in the SSC environment. Based on the theory of Yennie, Frautschi and Suura, we develop appropriate Monte Carlo event generators to compute the background electromagnetic radiation.
DeLaney, D. B., Jadach, S., Shio, Ch., Siopsis, G., Ward, B. F. L.   +4 more
core   +1 more source

A Census of X-ray gas in NGC 1068: Results from 450ks of Chandra HETG Observation

, 2013
We present models for the X-ray spectrum of the Seyfert 2 galaxy NGC 1068. These are fitted to data obtained using the High Energy Transmission Grating (HETG) on the Chandra X-ray observatory. The data show line and radiative recombination continuum (RRC)
Canizares, C., Evans, D. A., Kallman, T., Longinotti, A., Marshall, H., Nowak, M., Schulz, N.   +6 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Machine Learning Method for Monte Carlo Calculations of Radiative Processes

The Astrophysical Journal
Radiative processes such as synchrotron radiation and Compton scattering play an important role in astrophysics. Radiative processes are fundamentally stochastic in nature, and the best tools currently used for resolving these processes computationally ...
William Charles, Alexander Y. Chen
doaj   +1 more source