Results 31 to 40 of about 31,396 (258)
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
crash: a radiative transfer scheme [PDF]
Monthly Notices of the Royal Astronomical Society, 2003 We present a largely improved version of CRASH, a 3-D radiative transfer code that treats the effects of ionizing radiation propagating through a given inhomogeneous H/He cosmological density field, on the physical conditions of the gas. The code, based on a Monte Carlo technique, self-consistently calculates the time evolution of gas temperature and ...
MASELLI A., FERRARA, ANDREA, CIARDI B.
openaire +5 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Journal of Thermal Science and Technology, 2011 Thermal radiation in a turbulent natural convection plays an important role in a wide area of engineering and nature. The purposes of this study are to investigate the effects of turbulent fluctuation on radiative heat transfer, and to evaluate radiative
Atsushi SAKURAI +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Resonance Energy Transfer Molecular Imaging Application in Biomedicine
Journal of Isotopes, 2016 Resonance energy transfer molecular imaging (RETI) can markedly improve signal intensity and tissue penetrating capacity of optical imaging, and have huge potential application in the deep-tissue optical imaging in vivo.
NIE Da-hong1,2;TANG Gang-hua1,3
doaj +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
A Unifying Polarization Formalism for Electric and Magnetic Multipole Interactions
The Astrophysical JournalWe extend the spherical tensorial formalism for polarization to the treatment of electric and magnetic multipole transitions of any order. We rely on the spherical-wave expansion to derive the tensor form of the operator describing the interaction of the
R. Casini +3 more
doaj +1 more source