Results 111 to 120 of about 4,398,739 (376)

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

Pesantren dan Islam Puritan: Pelembagaan Tajdid Keagamaan di Lembaga Pendidikan Islam

Tsaqafah, 2015
In the 18th century, the leaders of Muslim reformers focused their movement to break the internal rigidity in the form of tauh}îd purification against the dominance of schools and heretical eradication which commonly called the religious purification ...
M. Arfan Mu’ammar
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

MULTIVISCERAL RESECTIONS IN CASES OF LOCALLY ADVANCED GASTRIC CANCER. PERIOPERATIVE RESULTS IN A HIGH-VOLUME CENTER [PDF]

Journal of IMAB
Introduction. At the time of diagnosis, gastric cancer is usually an advanced disease. This is related to poor prognosis. Despite of reported improvement of perioperative results after neoadjuvant therapy In cases of locally advanced disease without ...
Vesselin Marinov
doaj   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Rural-urban co-development - challenges to post-industrial society [PDF]

, 2002
The World Commission (1987) pointed out that sustainable development in general is a prerequisite to alleviate fatal threats to human future. In this note1 it is stated that it is necessary to return to basic concepts and reflections to ensure that the ...
Ingemann, Jan Holm
core  

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Opioid-free anesthesia for breast cancer surgery: An observational study

Journal of Anaesthesiology Clinical Pharmacology, 2018
Background and Aims: Opioids are associated with postoperative nausea, vomiting, drowsiness, and increased analgesic requirement. A nonopioid anesthesia technique may reduce morbidity, enable day care surgery, and possibly decrease tumor recurrence.
Swagata Tripathy, Satyajit Rath, Suresh Agrawal, P Bhaskar Rao, A Panda, T S Mishra, Sukdev Nayak   +6 more
doaj   +1 more source

Direct introduction of nitrogen and oxygen functionality with spatial control using copper catalysis. [PDF]

, 2018
Synthetic chemists have spent considerable effort optimizing the synthesis of nitrogen and oxygen containing compounds through a number of methods; however, direct introduction of N- and O-functionality remains challenging.
Fisher, David J, Limon, Luis, Read de Alaniz, Javier, Shaum, James B, Sroda, Miranda M   +4 more
core  

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source