Results 271 to 280 of about 4,601,498 (378)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Shining light on the mechanism of photochemical alkene formation in vitamin B₁₂. [PDF]

Chem Sci
Mukherjee A, Wu SY, Cooper DJ, Hendrickson R, Sension RJ, Lehnert N, Penner-Hahn JE.   +6 more
europepmc   +1 more source

Intervention strategies to modulate nitric oxide-derived free radicals [PDF]

Youssef El Amrani, Fatima Zahra Benali, Ahmed Chakir, Khadija Ouazzani   +3 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Trifluoromethyl Thianthrenium Salts: From Organic Synthesis to Materials. [PDF]

J Org Chem
Ji Y, Pleixats R, Gimbert-Suriñach C, Vallribera A, Granados A.   +4 more
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

The bismuth phosphanides Bi(PR₂)₃: sources of phosphanyl radicals, P-inversion, and reversible olefin insertion. [PDF]

Chem Sci
Reith S, Oberdorf K, Martínez S, Landgraf JB, Ahrens A, Jakobi F, Xie X, Lichtenberg C.   +7 more
europepmc   +1 more source

A tradução radical e alguns problemas para a linguística: : um ensaio [PDF]

Freisleben, Larissa Colombo
openalex