Results 61 to 70 of about 11,588 (242)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
CHIMIA, 1994 Radical-mediated phenylselanyl-group transfer reactions have been used to introduce simultaneously substituents at the C(6)-endo- and C(5)-exo-positions of 7-oxabicyclo[2.2.1]hept-5-en-2-one derivatives. The key steps are a radical addition to a
Philippe Renaud, Jean-Paul Vionnet
doaj +2 more sources
Syntheses of 3-O-Demethylthalicthuberine and N-Acetyl-seco-N-methyllaurotetanine [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2006 The structures previously assigned to the phenanthrene alkaloids 3-O-demethylthalicthuberine and N-acetyl-seco-N methyllaurotetanine have been confirmed by total syntheses in which the key step involved formation of ring C of the aporphine alkaloids ...
Rujee Lorpitthaya +2 more
doaj
Radical cyclizations to fluoroolefins.
Chemical and Pharmaceutical Bulletin, 1991 Radical cyclizations were effectively applied to systems containing fluoroolefins (α-fluoro-α, β-unsaturated ester, fluoroallyl acetate, gem-difluoroolefin, and fluorine-substituted unsaturated lactone) for the synthesis of ring compounds containing fluorine-substituted groups.
Tsutomu MORIKAWA +3 more
openaire +2 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2019 A diastereoselective approach to axially chiral imidazopyridine-containing biaryls has been developed. The reactions proceed through a radical cyclization cascade to construct the biaryls with good to excellent central-to-axial chirality transfer.
Hong Yan +4 more
doaj +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
A short synthesis of (±)-cherylline dimethyl ether
Beilstein Journal of Organic Chemistry, 2009 A synthesis of (±)-cherylline dimethyl ether is reported. The key steps involved are Michael-type addition, radical azidonation of an aldehyde, Curtius rearrangement, and reduction of an isocyanate intermediate followed by Pictet–Spengler cyclization.
Bhima Y. Kale +7 more
doaj +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source