Results 121 to 130 of about 480,674 (254)
France – Israel: consequences of the «October 7»
Научно-аналитический вестник Института Европы РАНOctober 7, 2023, the day of the Hamas extremist attack on Israel, marked the beginning of powerful upheavals in the Middle East region. They echoed in the form of large-scale demonstrations in many cities of the European Union and in the Euro-Atlantic ...
Alexander I. Shumilin
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Insight into Stable, Concentrated Radicals: from Sulfur-functionalized Alkyne-rich Crystalline Frameworks to Simple Alkyne Motifs [PDF]
Organic radicals feature versatile unpaired electrons key for photoelectronic and biomedical applications, but remain difficult to access in stable concentrated forms.
Jun, He +6 more
core +2 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Synthesis and hydroxyl radicals scavenging activity of quaternized carboxymethyl chitosan
, 2008 In order to determine the effect of the forms of the amido groups of chitosan on antioxidant activity, quaternized carboxymethyl chitosan (QCMC) derivatives were prepared with a degree of quaternization ranging from 34.3% to 59.5%.
Zhong, Zhimei +4 more
core
Organic radicals: formation, classification, and environmental application
Over the past two centuries, as our industries have boomed and our economies have thrived, air pollution has increasingly troubled us, tugging at our collective conscience. The rise of industries and the combustion of fossil fuels, such as coal, oil, and
Nazari M. +7 more
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source