Results 81 to 90 of about 480,674 (254)
Radical Addition to Iminium Ions and Cationic Heterocycles
Molecules, 2014 Carbon-centered radicals represent highly useful reactive intermediates in organic synthesis. Their nucleophilic character is reflected by fast additions to electron deficient C=X double bonds as present in iminium ions or cationic heterocycles.
Johannes Tauber +2 more
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
, 2017 Since from the second half of the last century the spin trapping has found wide applications in chemistry, biology and medicine [1]. Of particular interest are the studied of the free radicals induced in biologically active molecules, such as DNA and ...
LONGO, Anna +4 more
core
Mechanistic Aspects of the Photofunctionalisation of Tetraalkylammonium Cations by [PtCl6]2−
InorganicsUnexpected activation of the tetrabutylammonium cation in the presence of hexachloroplatinate(IV) under light to give a dinuclear complex of trans-μ2:η2,η2-1,3-butadiene-bis(trichloroplatinate(II)) along with a proposed mechanism of the activation has ...
Imelda H. Silalahi +7 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Multifrequency EPR study on radiation induced centers in calcium carbonates labeled with 13C
Nukleonika, 2015 In calcite and aragonite, γ-irradiated at 77 K, several paramagnetic centers were generated and detected by EPR spectroscopy; in calcite, CO3− (orthorhombic symmetry, bulk and bonded to surface), CO33−, NO32−, O3−, and in aragonite CO2− (isotropic and ...
Sadło Jarosław +4 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Oxidative Generation of Boron-Centered Radicals in Carboranes [PDF]
, 2019 We report the first indirect observation and use of boron vertex-centered carboranyl radicals generated by the oxidation of modified carboranyl precursors.
Alexander, Spokoyny +3 more
core +1 more source