Results 21 to 30 of about 87,781 (217)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

A Search for Persistent Radio Sources toward Repeating Fast Radio Bursts Discovered by CHIME/FRB

The Astrophysical Journal
The identification of persistent radio sources (PRSs) coincident with two repeating fast radio bursts (FRBs) supports FRB theories requiring a compact central engine.
Adaeze L. Ibik, Maria R. Drout, B. M. Gaensler, Paul Scholz, Navin Sridhar, Ben Margalit, T. E. Clarke, Casey J. Law, Shriharsh P. Tendulkar, Daniele Michilli, Tarraneh Eftekhari, Mohit Bhardwaj, Sarah Burke-Spolaor, Shami Chatterjee, Amanda M. Cook, Jason W. T. Hessels, Franz Kirsten, Ronniy C. Joseph, Victoria M. Kaspi, Mattias Lazda, Kiyoshi W. Masui, Kenzie Nimmo, Ayush Pandhi, Aaron B. Pearlman, Ziggy Pleunis, Masoud Rafiei-Ravandi, Kaitlyn Shin, Kendrick M. Smith   +27 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Polarization Characteristics of the Hyperactive FRB 20240114A

The Astrophysical Journal Supplement Series
Fast radio bursts (FRBs) are transient radio bursts of extragalactic origin characterized by millisecond durations and high luminosities. We report on observations of FRB 20240114A conducted with the Robert C.
Jin-Tao Xie, Yi Feng, Di Li, Yong-Kun Zhang, Deng-Ke Zhou, Yuanhong Qu, Xiang-han Cui, Jian-Hua Fang, Jia-Ying Xu, Chen-Chen Miao, Mao Yuan, Chao-Wei Tsai, Pei Wang, Chen-Hui Niu, Xianglei Chen, Mengyao Xue, Junshuo Zhang   +16 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Updating the First CHIME/FRB Catalog of Fast Radio Bursts with Baseband Data

The Astrophysical Journal
In 2021, a catalog of 536 fast radio bursts (FRBs) detected with the Canadian Hydrogen Intensity Mapping Experiment (CHIME) radio telescope was released by the CHIME/FRB Collaboration.
The CHIME/FRB Collaboration, Mandana Amiri, Bridget C. Andersen, Shion Andrew, Kevin Bandura, Mohit Bhardwaj, P. J. Boyle, Charanjot Brar, Daniela Breitman, Tomas Cassanelli, Pragya Chawla, Amanda M. Cook, Alice P. Curtin, Matt Dobbs, Fengqiu Adam Dong, Gwendolyn Eadie, Emmanuel Fonseca, B. M. Gaensler, Utkarsh Giri, Antonio Herrera-Martin, Hans Hopkins, Adaeze L. Ibik, Ronniy C. Joseph, J. F. Kaczmarek, Zarif Kader, Victoria M. Kaspi, Adam E. Lanman, Mattias Lazda, Calvin Leung, Siqi Liu, Kiyoshi W. Masui, Ryan Mckinven, Juan Mena-Parra, Marcus Merryfield, Daniele Michilli, Cherry Ng, Kenzie Nimmo, Gavin Noble, Ayush Pandhi, Chitrang Patel, Aaron B. Pearlman, Ue-Li Pen, Emily Petroff, Ziggy Pleunis, Masoud Rafiei-Ravandi, Mubdi Rahman, Scott M. Ransom, Ketan R. Sand, Paul Scholz, Vishwangi Shah, Kaitlyn Shin, Yuliya Shpunarska, Seth R. Siegel, Kendrick Smith, Ingrid Stairs, David C. Stenning, Keith Vanderlinde, Haochen Wang, Henry White, Dallas Wulf   +59 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Radio Afterglows from Tidal Disruption Events: An Unbiased Sample from ASKAP RACS

The Astrophysical Journal
Late-time (∼a year) radio follow-up of optically discovered tidal disruption events (TDEs) is increasingly resulting in detections at radio wavelengths, and there is growing evidence for this late-time radio activity to be common to the broad class of ...
Akash Anumarlapudi, Dougal Dobie, David L. Kaplan, Tara Murphy, Assaf Horesh, Emil Lenc, Laura Driessen, Stefan W. Duchesne, Hannah Dykaar, B. M. Gaensler, Timothy J. Galvin, Joe Grundy, George Heald, Aidan W. Hotan, Minh Huynh, James K. Leung, David McConnell, Vanessa A. Moss, Joshua Pritchard, Wasim Raja, Kovi Rose, Gregory Sivakoff, Yuanming Wang, Ziteng Wang, Mark H. Wieringa, Matthew T. Whiting   +25 more
doaj   +1 more source