Results 41 to 50 of about 87,781 (217)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

A Sample of Short-lived Galactic Radio Transients from ASKAP VAST

The Astrophysical Journal
Galactic radio transients (GRTs) are mysterious short-lived (∼days to months) radio transients that are quiet at all other wavelengths. Until now, roughly half a dozen such sources have been reported, predominantly towards the Galactic center.
Akash Anumarlapudi, David L. Kaplan, Natasha Hurley-Walker, Stella Koch Ocker, Daniel Kelson, Dougal Dobie, Laura Driessen, Tara Murphy, Joshua Pritchard   +8 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

The Cosmic Evolution of Fast Radio Bursts Inferred from the CHIME/FRB Baseband Catalog 1

The Astrophysical Journal
Redshift and luminosity distributions are essential for understanding the cosmic evolution of extragalactic objects and phenomena, such as galaxies, gamma-ray bursts, and fast radio bursts (FRBs).
Om Gupta, Paz Beniamini, Pawan Kumar, Steven L. Finkelstein   +3 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

The Variability of Persistent Radio Sources of Fast Radio Bursts

The Astrophysical Journal
Over 700 bright millisecond-duration radio transients, known as fast radio bursts (FRBs), have been identified to date. Nevertheless, the origin of FRBs remains unknown.
Ai Yuan Yang, Yi Feng, Chao-Wei Tsai, Di Li, Hui Shi, Pei Wang, Yuan-Pei Yang, Yong-Kun Zhang, Chen-Hui Niu, Ju-Mei Yao, Yu-Zhu Cui, Ren-Zhi Su, Xiao-Feng Li, Jun-Shuo Zhang, Yu-Hao Zhu, W. D. Cotton   +15 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A Deep VLA Search for a Persistent Radio Counterpart to the One-off FRB 20250316A

The Astrophysical Journal Letters
Fast radio burst (FRB) 20250316A, detected by CHIME on 2025 March 16 with a fluence of 1.7 ± 0.1 kJy ms and a dispersion measure of 161.3 ± 0.4 pc cm ^−3 , ranks among the brightest extragalactic FRBs at ∼40 Mpc. We obtain deep Karl G.
Tao An, Ailing Wang, Yu-Chen Huang, Jia-Pei Feng, Yuanqi Liu, Zhongli Zhang, Zi-Gao Dai   +6 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source