Results 71 to 80 of about 140,601 (311)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

A Target Search for Fast Radio Bursts Associated with Two Fast Blue Optical Transients: AT2018cow and CSS161010

The Astrophysical Journal
Fast blue optical transients (FBOTs) are luminous, rapidly evolving events with blue spectra, possibly powered by newborn magnetars and linked to fast radio bursts (FRBs).
Shi-Jie Gao, Xiang-Dong Li, Yi-Xuan Shao, Ping Zhou, Pei Wang, Yun-Wei Yu, Zhen Yan, Di Li   +7 more
doaj   +1 more source

New Limits on Radio Emission from X-ray Dim Isolated Neutron Stars [PDF]

, 2009
We have carried out a search for radio emission at 820 MHz from six X-ray dim isolated neutron stars with the Robert C. Byrd Green Bank Radio Telescope.
A. Possenti, Aguilera, Bracewell, Burns, Camilo, Cordes, Cordes, Cordes, D. R. Lorimer, Evans, Faucher-Giguere, Gonzalez, Gotthelf, Haberl, Haberl, Hankins, Haslam, Ibrahim, Johnson, Kaplan, Kaplan, Kaplan, Kaplan, Kaplan, Kaplan, Kaplan, Kaplan, Kaspi, Kramer, Kulkarni, Lorimer, Lyne, M. A. McLaughlin, M. Burgay, McLaughlin, McLaughlin, McLaughlin, McLaughlin, Motch, Motch, Page, Pivovaroff, Popov, R. Turolla, Radhakrishnan, Ransom, Rutledge, S. B. Popov, S. Zane, Schwope, Tiengo, V. I. Kondratiev, van Kerkwijk, van Kerkwijk, Voges, Vranesevic, Walter, Weltevrede, Zane, Zane   +59 more
core   +3 more sources

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Bright Bursts with Submillisecond Structures of FRB 20230607A in a Highly Magnetized Environment

The Astrophysical Journal
We report the observations of a repeating FRB 20230607A for 15.6 hr spanning 16 months using the Five-hundred-meter Aperture Spherical Radio Telescope with the detection of 565 bursts.
DeJiang Zhou, J. L. Han, Bing Zhang, WeiWei Zhu, Wei-yang Wang, Yuan-Pei Yang, Yuanhong Qu, Yong-Kun Zhang, Yi Yan, Wei-Cong Jing, Shuo Cao, Jintao Xie, Xuan Yang, Shiyan Tian, Ye Li, Dongzi Li, Jia-Rui Niu, Zi-Wei Wu, Qin Wu, Yi Feng, Fayin Wang, Pei Wang   +21 more
doaj   +1 more source

On the use of variability time-scales as an early classifier of radio transients and variables [PDF]

, 2017
We have shown previously that a broad correlation between the peak radio luminosity and the variability time-scales, approximately L ~ t^5, exists for variable synchrotron emitting sources and that different classes of astrophysical source occupy ...
Fender, R. P., Pietka, M., Pretorius, M. L., Staley, T. D.   +3 more
core   +3 more sources

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

An automated archival VLA transients survey

, 2011
In this paper we present the results of a survey for radio transients using data obtained from the Very Large Array archive. We have reduced, using a pipeline procedure, 5037 observations of the most common pointings - i.e. the calibrator fields.
B. Scheers, B. W. Stappers, Bannister, Bastian, Becker, Becker, Bell, Bhat, Bower, Bower, Bower, Bower, Bower, C. J. Law, Carilli, Cohen, Condon, Cordes, Croft, Davies, de Vries, Eck, Frail, Frail, Gaensler, Gal-Yam, Greisen, H. Spreeuw, Hodapp, Hopkins, Hyman, Hyman, Högbom, J. C. A. Miller-Jones, J. Masters, J. Swinbank, J. W. T. Hessels, Johnston, Jones, Kettenis, Kida, Kuniyoshi, Lazio, Lenc, Levinson, Lonsdale, M. E. Bell, M. W. Wise, Matsumura, McLaughlin, Niinuma, Niinuma, Ofek, R. A. M. J. Wijers, R. P. Fender, Rau, Rengelink, Stappers, Swinbank, van den Oord, Verheijen, Welch, White, White, Zhao   +64 more
core   +1 more source

Towards 4U 1630-47: a black-hole soft X-ray transient odyssey [PDF]

, 1998
4U 1630-47 is a black-hole X-ray transient with one of the shortest recurrence times. Despite its regular outburst behaviour little is known about this source. Only recently has attention to this system increased.
Kuulkers, Erik
core   +4 more sources