Results 71 to 80 of about 4,766,380 (340)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Polarization Characteristics of the Hyperactive FRB 20240114A

The Astrophysical Journal Supplement Series
Fast radio bursts (FRBs) are transient radio bursts of extragalactic origin characterized by millisecond durations and high luminosities. We report on observations of FRB 20240114A conducted with the Robert C.
Jin-Tao Xie, Yi Feng, Di Li, Yong-Kun Zhang, Deng-Ke Zhou, Yuanhong Qu, Xiang-han Cui, Jian-Hua Fang, Jia-Ying Xu, Chen-Chen Miao, Mao Yuan, Chao-Wei Tsai, Pei Wang, Chen-Hui Niu, Xianglei Chen, Mengyao Xue, Junshuo Zhang   +16 more
doaj   +1 more source

A CHIME/FRB Study of Burst Rate and Morphological Evolution of the Periodically Repeating FRB 20180916B

The Astrophysical Journal, 2023
FRB 20180916B is a repeating fast radio burst (FRB) with a 16.3 day periodicity in its activity. In this study, we present morphological properties of 60 FRB 20180916B bursts detected by CHIME/FRB between 2018 August and 2021 December.
Ketan R. Sand, Daniela Breitman, Daniele Michilli, Victoria M. Kaspi, Pragya Chawla, Emmanuel Fonseca, Ryan Mckinven, Kenzie Nimmo, Ziggy Pleunis, Kaitlyn Shin, Bridget C. Andersen, Mohit Bhardwaj, P. J. Boyle, Charanjot Brar, Tomas Cassanelli, Amanda M. Cook, Alice P. Curtin, Fengqiu Adam Dong, Gwendolyn M. Eadie, B. M. Gaensler, Jane Kaczmarek, Adam Lanman, Calvin Leung, Kiyoshi W. Masui, Mubdi Rahman, Ayush Pandhi, Aaron B. Pearlman, Emily Petroff, Masoud Rafiei-Ravandi, Paul Scholz, Vishwangi Shah, Kendrick Smith, Ingrid Stairs, David C. Stenning   +33 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A Systematic Analysis of the Radio Properties of 22 X-Ray-selected Tidal Disruption Event Candidates with the Australia Telescope Compact Array [PDF]

Astrophysical Journal Supplement Series
We present a systematic analysis of the radio properties of an X-ray-selected sample of tidal disruption event (TDE) candidates discovered by the eROSITA telescope.
A. Goodwin, M. Burn, G. Anderson, J. Miller-Jones, I. Grotova, P. Baldini, Z. Liu, A. Malyali, A. Rau, M. Salvato   +9 more
semanticscholar   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

A Target Search for Fast Radio Bursts Associated with Two Fast Blue Optical Transients: AT2018cow and CSS161010

The Astrophysical Journal
Fast blue optical transients (FBOTs) are luminous, rapidly evolving events with blue spectra, possibly powered by newborn magnetars and linked to fast radio bursts (FRBs).
Shi-Jie Gao, Xiang-Dong Li, Yi-Xuan Shao, Ping Zhou, Pei Wang, Yun-Wei Yu, Zhen Yan, Di Li   +7 more
doaj   +1 more source

The Open mulTiwavelength Transient Event Repository (OTTER): Infrastructure Release and Tidal Disruption Event Catalog [PDF]

Astrophysical Journal
Multiwavelength analyses of astrophysical transients are essential for understanding the physics of these events. To make such analyses more efficient and effective, we present the Open mulTiwavelength Transient Event Repository (OTTER), a publicly ...
Noah Franz, K. Alexander, Sebastian Gomez, Collin T. Christy, T. Laskar, S. van Velzen, N. Earl, S. Gezari, M. Karmen, R. Margutti, J. Pearson, V. Villar, A. Zabludoff   +12 more
semanticscholar   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Bright Bursts with Submillisecond Structures of FRB 20230607A in a Highly Magnetized Environment

The Astrophysical Journal
We report the observations of a repeating FRB 20230607A for 15.6 hr spanning 16 months using the Five-hundred-meter Aperture Spherical Radio Telescope with the detection of 565 bursts.
DeJiang Zhou, J. L. Han, Bing Zhang, WeiWei Zhu, Wei-yang Wang, Yuan-Pei Yang, Yuanhong Qu, Yong-Kun Zhang, Yi Yan, Wei-Cong Jing, Shuo Cao, Jintao Xie, Xuan Yang, Shiyan Tian, Ye Li, Dongzi Li, Jia-Rui Niu, Zi-Wei Wu, Qin Wu, Yi Feng, Fayin Wang, Pei Wang   +21 more
doaj   +1 more source