Results 161 to 170 of about 247,599 (314)

Clinical Pharmacokinetics, Mass Balance and Metabolism of Fezolinetant in Postmenopausal Women. [PDF]

Eur J Drug Metab Pharmacokinet
Iwai M, Souda K, Miyagawa M, Nielsen JC, Chappa A, Fraser GL, Ramael S, Brouwer JLP, Huang J.   +8 more
europepmc   +1 more source

Spatially resolved 23Na magnetic resonance dispersion measurement in porous media

The Canadian Journal of Chemical Engineering, EarlyView.
Quantitative 23Na MRI was employed to analyze dispersion in realistic core plug samples and was compared with the conventional breakthrough curve. 23Na MRI provided a more effective aassessment of core plug heterogeneity than the conventional method. Abstract Tracer tests are widely used in the petroleum industry to assess reservoir core plugs, relying
Rheya Rajeev, Mohammad Sadegh Zamiri, Andrés Ramírez Aguilera, Florea Marica, Laura Romero de Zerón, Bruce J. Balcom   +5 more
wiley   +1 more source

A Phase 1 Microtracer Study Evaluating the Mass Balance, Excretion, and Pharmacokinetics of Osivelotor in Healthy Participants. [PDF]

Clin Transl Sci
Zimmerman EI, Callegari E, Sharma R, Adenola A, Volpe J, Seetharaman K, Zhang C, Duchin K, Walker GS.   +8 more
europepmc   +1 more source

Isoform Specificity of a Compound Targeting Actin Filaments Containing Tropomyosin Tpm1.8/1.9

Cytoskeleton, EarlyView.
ABSTRACT The unbranched actin filaments in mammalian cells are usually composed of co‐polymers of a specific tropomyosin isoform with actin. Genetic manipulation has revealed that the tropomyosins largely define the functional properties of actin filaments in an isoform‐specific, non‐redundant manner.
Jeff Hook, Edna C. Hardeman, Peter W. Gunning   +2 more
wiley   +1 more source

Assessment of radiological hazards arising from natural radioactivity in Bayburt stones used in buildings and possible effects on public health. [PDF]

Front Public Health
Dizman S, Umar M, Hatipoglu YS.
europepmc   +1 more source

Payload‐Based Clinical Pharmacology Review of Approved Antibody–Drug Conjugates: Commonalities and Considerations for Streamlined Development

Clinical Pharmacology &Therapeutics, EarlyView.
Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu, Qingqing Xiao, Lixuan Qian, Siyuan Sun, Zhu Zhou, Michael Z. Liao, Chunze Li   +6 more
wiley   +1 more source

Human Absorption, Metabolism, and Excretion (hAME) Mass Balance Studies in Patients With Cancer. [PDF]

Clin Transl Sci
Heras BL, Oelke C, Atwell P, Herrero H, Nunes P, Saini KS, Boixader LV, Laing C, Bush J, Calvo E.   +9 more
europepmc   +1 more source

Clinical Characterization of Enzyme and Transporter Precipitants to Evaluate Drug–Drug Interactions for Orforglipron, a Small Molecule Glucagon‐Like Peptide‐1 Receptor Agonist

Clinical Pharmacology &Therapeutics, EarlyView.
Orforglipron is an orally administered, small‐molecule glucagon‐like peptide‐1 receptor agonist in clinical development for the treatment of type 2 diabetes and obesity. Orforglipron is a substrate of CYP3A4, organic anion transporting polypeptides (OATPs) 1B/1B3, and P‐glycoprotein (P‐gp); however, precipitants commonly used to define these mechanisms
Bridget L. Morse, David E. Coutant, Xiaosu Ma, Sohini Raha, Keerthan Aithal, Clare Nicoll, Luc R. A. Rougée, Shobha Bhattachar   +7 more
wiley   +1 more source

A Phase 1 Oral Mass Balance and Combined Intravenous [¹⁴C] Microtracer Study to Characterize the Absorption, Metabolism, Excretion, and Pharmacokinetics of Antitumor Drug E7386 in Humans. [PDF]

J Clin Pharmacol
Pathak SM, Hayata N, Ueno T, Aluri J, Wu J, Brooks AS, Laing CM, Dutta L, Yasuda S.   +8 more
europepmc   +1 more source

Effects of Trimethoprim on Three Previously Proposed Putative Biomarkers for OCT2/MATE‐Mediated Renal Drug‐Drug Interactions in Healthy Volunteers

Clinical Pharmacology &Therapeutics, EarlyView.
Regulatory agencies request the assessment of the potential of new drugs to cause transporter‐mediated drug‐drug interactions (DDI). This assessment can be improved by integrating endogenous biomarkers during drug development. Regarding the renal excretion of drugs such as metformin, the organic cation transporter (OCT) 2 and multidrug and toxin ...
Jana Picurová, Fabian Müller, Daniel Auge, Jörg König, Martin F. Fromm, Arne Gessner   +5 more
wiley   +1 more source