Results 231 to 240 of about 37,305 (281)

Pharmacokinetics, Mass Balance, and Biotransformation of [¹⁴C]tinengotinib, A Novel Multi-target Kinase Inhibitor, in Healthy Subjects. [PDF]

Drugs R D
Ni S, Ma S, Yu Y, Yu Z, Zhu Y, Sun X, Li L, Sun C, Wang H, Peng P, Gu Z, Zhang H, Wu F, Miao L, Fan J.   +14 more
europepmc   +1 more source

A PK/PD study on antihyperalgesia by an α2/3‐GABAA receptor PAM in mice: Lack of tolerance liability and potential involvement of γ1‐GABAA receptors

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose GABAA receptors (GABAARs) are heteropentameric ion channels that control almost all CNS functions, including spinal nociception. Most GABAARs contain a γ2 subunit but differ in their α and β subunit composition. TPA023B is an α2/α3 subtype selective, non‐sedative, positive allosteric modulator (PAM) with antihyperalgesic
Elena Neumann, Mariana O. Popa, Karen T. Elvers, Misa Oyama, Daniel Ulrich, Marcus Hanley, Gui Jie Feng, Thomas Hathaway, William T. Ralvenius, Thomas Grampp, Dietmar Benke, John R. Atack, Hanns Ulrich Zeilhofer   +12 more
wiley   +1 more source

Eco-Friendly Polysaccharides as Moisture Retainers: Influence on Humic Acid Colloidal Stability in Model and Natural Systems. [PDF]

Molecules
Trishkin GN, Chernysheva MG, Kulikova NA, Badun GA.   +3 more
europepmc   +1 more source

Matsupexole: A novel nonergot dopamine receptor agonist with sustained efficacy in a rat model of Parkinson's disease and limited off‐target activity

British Journal of Pharmacology, EarlyView.
Background and Purpose Dopamine receptor agonists, particularly targeting the dopamine D2L receptor (D2LR), have been used to treat Parkinson's disease (PD). However, valvular heart disease and somnolence, mainly caused by activating the serotonin 5‐HT2B receptor (5‐HT2BR) and dopamine D3 receptor (D3R), respectively, currently challenge their clinical
Takayuki Suzuki, Fumiki Oana, Masaki Oota, Yuma Handa, Osamu Kaminuma   +4 more
wiley   +1 more source

Evaluation of radioactivity in chanterelle (Cantharellus cibarius) and health implications. [PDF]

Environ Geochem Health
Strumińska-Parulska D, Moniakowska A, Szymańska K, Falandysz J.   +3 more
europepmc   +1 more source

Second‐generation prokineticin PKR1 receptor agonists: Advancing cardioprotection against chemotherapy‐induced toxicity

British Journal of Pharmacology, EarlyView.
IS39, a novel non‐peptide PKR1 agonist, confers cardioprotection against doxorubicin‐induced toxicity. IS39 activates PKR1‐mediated pro‐survival signalling in cardiomyocytes, reducing reactive oxygen species (ROS), DNA damage and fibrosis markers. In vivo, IS39 preserves cardiac geometry and function in mice exposed to chronic doxorubicin challenge ...
Anais Audebrand, Simone Brogi, Mustafa Tezeren, Andrea Tafi, Omer H. Ocak, Hasan Koyuncu, Igor Tetko, Laurent Désaubry, Canan G. Nebigil   +8 more
wiley   +1 more source

Efficient Coextraction of U(VI), Np(V), and Pu(IV) Using Tetradentate N‑Heterocyclic Amide-Triazine Extractants. [PDF]

Chem Bio Eng
Yang X, Wang Y, Fang D, Wang S, Li Z, Zhang A, Xiao C.   +6 more
europepmc   +1 more source

Revolutionizing cancer treatment: The role of radiopharmaceuticals in modern cancer therapy. [PDF]

Precis Radiat Oncol
Varghese TP, John A, Mathew J.
europepmc   +1 more source

Awareness of Seafood Safety Concerning Radioactivity: Country-Based Comparisons of Food Safety Issues. [PDF]

Foods
Kyung MS, Do HW, Seo JW, Moon WW, Ham S.
europepmc   +1 more source

Contamination and Decontamination of Various Fibers by Radioactive Substances

RADIOISOTOPES, 1956
openaire   +2 more sources