Results 31 to 40 of about 25,870 (184)

Metrological assurance in radiochemical production

Стандартные образцы, 2017
Introduction: Radiochemical production is one of the richest in terms of data for analytical control, high-quality implementation of which is impossible without using type approved reference materials (RMs).
Yuliya A. Tadevosyan, Maksim A. Semenov, Elena S. Kiseleva   +2 more
doaj   +1 more source

Multifactorial analysis of radiochemical purity in high-activity ¹⁷⁷Lu-labeled theranostics: impact of precursor source, ¹⁷⁷Lu form, and production parameters. [PDF]

EJNMMI Radiopharm Chem
Background Lutetium-177 (177Lu) theranostics have revolutionized personalized cancer treatment, particularly with FDA-approved therapies like [177Lu]Lu-DOTA-TATE for neuroendocrine tumors and [177Lu]Lu-PSMA for prostate cancer.
Hunt W, Long M, Kamil U, Kellapatha S, Noonan W, Roselt PD, Papa N, Emmerson B, Hofman MS, Haskali MB.   +9 more
europepmc   +2 more sources

Synthesis of [18F]FMISO, a hypoxia-specific imaging probe for PET, an overview from a radiochemist’s perspective

EJNMMI Radiopharmacy and Chemistry, 2023
Background [18F]fluoromisonidazole ([18F]FMISO, 1H-1-(3-[18F]fluoro-2-hydroxypropyl)-2-nitroimidazole) is a commonly used radiotracer for imaging hypoxic conditions in cells.
Torsten Kniess, Jörg Zessin, Peter Mäding, Manuela Kuchar, Oliver Kiss, Klaus Kopka   +5 more
doaj   +1 more source

An HPLC and UHPLC-HRMS approach to study PSMA-11 instability in aqueous solution

EJNMMI Radiopharmacy and Chemistry, 2021
Background The stability of precursors and reagents is of utmost importance for developing a robust radiolabelling method that provides high and constant radiochemical yield and radiochemical purity.
Antonella Iudicello, Filippo Genovese, Valentina Di Iorio, Gianfranco Cicoria, Stefano Boschi   +4 more
doaj   +1 more source

Optimization of Automatic Synthesis and Separation of [18F] AV-45 and Quality Control

Frontiers in Chemistry, 2022
Objective: Based on the Tracerlab FXF-N platform, a synthesis program and preparative high-performance liquid chromatography (HPLC) purification program edited by us can stably and repeatedly produce [18F] AV-45 without changing the process. The [18F] AV-
Qi-Zhou Zhang, Yu-Bin Li, Nazi Yilihamu, Xiao-Hong Li, Ya Ba, Yong-De Qin   +5 more
doaj   +1 more source

Removal of cadmium and (radio)toxic metal ions using activated sludge-based sorbents

Sustainable Chemistry for the Environment
Biochars produced from sewage sludge were investigated towards their adsorption capacity for cadmium and (radio)toxic metals. Samples of waste sewage sludge were subjected to pyrolysis at 350, 450 and 800 °C.
Maria Kapnisti, Konstantinos Lanaras, Aikaterini Liaska, Fotini Noli, Petros Samaras   +4 more
doaj   +1 more source

On site production of [18F]PSMA-1007 using different [18F]fluoride activities: practical, technical and economical impact

EJNMMI Radiopharmacy and Chemistry, 2021
Background Prostate-specific membrane antigen is overexpressed in prostate cancer and it is considered a good target for positron emission tomography/computed tomography imaging of primary cancer and recurrent/metastatic disease, as well as for ...
Costantina Maisto, Anna Morisco, Roberta de Marino, Elisabetta Squame, Valentina Porfidia, Laura D’Ambrosio, Daria Di Martino, Paolo Gaballo, Michela Aurilio, Monica Buonanno, Aureliana Esposito, Marco Raddi, Secondo Lastoria   +12 more
doaj   +1 more source

Fundamental concepts of radiopharmaceuticals quality controls

Pharmaceutical and Biomedical Research, 2018
Quality control (QC) procedures should always be performed following radiopharmaceutical preparation and prior to patient administration. The main aim of QC is to ensure optimal radiopharmaceutical product properties except for some short half-life ...
Sajjad Molavipordanjani, Seyed Jalal Hosseinimehr   +1 more
doaj  

The Semi-automatic Synthesis of 18F-fluoroethyl-choline by Domestic FDG Synthesizer

Journal of Isotopes, 2016
As an important complementary imaging agent for 18F-FDG, 18F-fluoroethyl-choline (18F-FECH) has been demonstrated to be promising in brain and prostate cancer imaging.
ZHOU Ming, ZHANG Xiao-jun, LIU Jian, LI Yun-gang   +3 more
doaj   +1 more source

Design and radiosynthesis of class-IIa HDAC inhibitor with high molar activity via repositioning the 18F-radiolabel

Scientific Reports
The design and radiosynthesis of [18F]NT376, a high potency inhibitor of class-IIa histone deacetylases (HDAC) is reported. We utilized a three-step radiochemical approach that led to the radiosynthesis of [18F]NT376 in a good radiochemical yield, (17.0 ±
Sulan Xu, Chun-Han Huang, Christopher Eyermann, Georgios V. Georgakis, Nashaat Turkman   +4 more
doaj   +1 more source