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Electrochemical Radiofluorination of Small Molecules: New Advances
The Chemical Record, 2021AbstractThe development of new 18F‐based radiopharmaceuticals constantly demands innovations in the search for new radiofluorination methods. [18F]fluoride is the simplest and most convenient chemical form of the isotope for the synthesis of 18F‐based radiopharmaceuticals.
Daniel Hernández‐Valdés +1 more
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Enzymatic Radiofluorination: Current Status
Current Radiopharmaceuticalse, 2010This review provides a overview of the use of biocatalysts in fluorine-18 chemistry that have emerged so far. The preparation of the following radiolabelled counpunds are discussed: [18F]5-FDA, [18F]5-FDI, [18F]5-FDR using different enzyme combinations. Nethertheless, the major emphasis is placed on the use of a key enzyme (ie the fluorinase) mediating
L. Martarello, C. Plisson, A.D. Gee
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ChemInform Abstract: Aliphatic Nucleophilic Radiofluorination
ChemInform, 2011AbstractReview: 171 refs.
Dirk Roeda, Frederic Dolle
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Protodeboronation: a Major Challenge in Copper-mediated Radiofluorination
Nuclear Medicine and BiologyS. Kaur +3 more
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Enzymatically Catalyzed Radiofluorination of Biomolecules
2019There has been significant and rapid growth in the development of amino acid-based molecular imaging agents (e.g., peptides, proteins, and antibody constructs) largely due to facile library preparation and high throughput screening. Positron-emitting fluorine-18 (half-life = 109.7 min) has a unique set of properties that match well with the ...
Christopher R, Drake +2 more
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The 18F radiofluorination of arylsilanes
Journal of the Chemical Society, Chemical Communications, 1984Fluoration par 18 F 2 d'(aryl trialkyl) silanes, et obtention de fluoro-, (cyano-1 fluoro-4)- et (chloro-1 fluoro-4 ...
Pasquale Di Raddo +2 more
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Journal of Medicinal Chemistry
The 18 kDa translocator protein (TSPO) is a critical target for PET imaging of neuroinflammation in central nervous system (CNS) disorders; however, many clinical TSPO PET tracers are limited by sensitivity to rs6971 polymorphism.
Wenqing Ran +22 more
semanticscholar +1 more source
The 18 kDa translocator protein (TSPO) is a critical target for PET imaging of neuroinflammation in central nervous system (CNS) disorders; however, many clinical TSPO PET tracers are limited by sensitivity to rs6971 polymorphism.
Wenqing Ran +22 more
semanticscholar +1 more source
H18F + Sb2O3: a new selective radiofluorinating agent
Journal of the Chemical Society, Chemical Communications, 1986A simple route is described to introduce fluorine-18 into a trihalogenomethyl group in 20–50% yield, using a new selective fluorinating agent (H18F + Sb2O3).
ANGELINI, Giancarlo +3 more
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Recent Progress on Radiofluorination using Metals: Strategies for Generation of C-18F Bonds
Organic Chemistry Frontiers, 2023C-F bond formation is an important research topic in organic synthesis because of the wide use of organofluorine compounds in various areas including pharmaceuticals, agricultural applications, and materials science.
Truong Giang Luu, Hee‐Kwon Kim
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The Current Role of Microfluidics in Radiofluorination Chemistry
Molecular Imaging and Biology, 2019The current utilization of positron emission tomography (PET) imaging is limited due to the high costs associated with production facility start-up and operations; subsequently, there has been a movement towards microfluidic synthesis of radiolabeled imaging pharmaceuticals (tracers).
Karla-Anne, Knapp +2 more
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