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Radiofluorinated Carbohydrates for Positron Emission Tomography
Current Topics in Medicinal Chemistry, 20132-Deoxy-2-[(18)F]fluoro-D-glucose (2-(18)FDG) has represented radiofluorinated carbohydrates as the most successful tracer for positron emission tomography (PET). 2-(18)FDG uptake depends on glucose metabolism, which is related to a disease progression.
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Homogeneous Nucleophilic Radiofluorination and Fluorination with Phosphazene Hydrofluorides
Chemistry – A European Journal, 2011AbstractA series of phosphazenium hydrofluorides, P1tBu⋅[18/19F]HF, P1tOct⋅[18/19F]HF, P2Et⋅[18/19F]HF, and P4tBu⋅[18/19F]HF, was synthesized. The radioactive phosphazenium [18F]hydrofluorides were obtained by the one‐step formation and trapping of gaseous [18F]HF with the respective phosphazene bases.
Bente, Mathiessen +2 more
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Hypervalent aryliodine compounds as precursors for radiofluorination
Journal of Labelled Compounds and Radiopharmaceuticals, 2018Over the last 2 decades or so, hypervalent iodine compounds, such as diaryliodonium salts and aryliodonium ylides, have emerged as useful precursors for labeling homoarenes and heteroarenes with no‐carrier‐added cyclotron‐produced [18F]fluoride ion (t1/2 = 109.8 min).
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Single-step radiofluorination of peptides using continuous flow microreactor
Organic & Biomolecular Chemistry, 201218F radiolabelling of peptides bearing two different prosthetic groups was successfully conducted in a continuous flow microfluidic device for the first time. Radiochemical yields were dependent on precursor concentration, reaction temperature and flow rate. The choice of leaving group had a dramatic influence on the reaction outcome.
Svetlana V, Selivanova +6 more
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Radiofluorinated Enzyme Probes of Dopaminergic Function
1995Radiofluorinated analogs of enzyme substrates offer a useful strategy for designing radiotracers to probe or label specific enzymes and their function (1). They are being used to investigate the dopaminergic system in vivo to obtain information about the structural requirements associated with neurotransmitter enzyme function as well as critical ...
Jorge R. Barrio +3 more
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Thermolysis and radiofluorination of diaryliodonium salts derived from anilines
Organic & Biomolecular Chemistry, 2017Mechanistic and theoretical studies reveal new reactions of Ar2I salts that can interfere with radiolabeling of these substrates.
Ethan J. Linstad +5 more
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Journal of Organic Chemistry
Conjugation of radiofluorinated prosthetic groups to primary amines of peptides in an aqueous medium is still considerably challenging. Herein, we report a one-pot cascade synthesis of 1-[18F]fluoro-4-isothiocyanatobenzene ([18F]2d), an isothiocyanate ...
S. Gundam +2 more
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Conjugation of radiofluorinated prosthetic groups to primary amines of peptides in an aqueous medium is still considerably challenging. Herein, we report a one-pot cascade synthesis of 1-[18F]fluoro-4-isothiocyanatobenzene ([18F]2d), an isothiocyanate ...
S. Gundam +2 more
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Radiofluorination and reductive amination using a microfluidic device
Journal of Labelled Compounds and Radiopharmaceuticals, 2012A commercial microfluidic device (NanoTek, Advion) was used as a synthesis platform for the preparation of fluorine‐18 labelled tertiary amines in two consecutive steps. Firstly, the nucleophilic radiofluorination of an aromatic aldehyde and secondly, the reductive amination to produce the corresponding amine.
Kenneth Dahl +2 more
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No-carrier-added electrochemical nucleophilic radiofluorination of aromatics
Journal of Radioanalytical and Nuclear Chemistry, 2014Direct nucleophilic radiosynthesis of di-tert-butyl-(4-[18F]fluoro-1,2-phenylene)-dicarbonate was conducted through no-carrier-added electrochemical reactions. 10 mM of triethylamine acetic acid (Et3N·3HAc) in acetonitrile was used to release [18F]fluoride ion trapped in the quaternary ammonium anion exchange resin.
Qinggang He, Ines Alfeazi, Saman Sadeghi
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Aliphatic Nucleophilic Radiofluorination
Current Radiopharmaceuticalse, 2010Dirk Roeda, Frederic Dolle
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