Results 71 to 80 of about 987,086 (294)

Development of MDM2‐Targeting PROTAC for Advancing Bone Regeneration

Advanced Science, EarlyView.
This work presents a creative pipeline for developing MDM2‐targeting PROTACs (MDM2‐PROTACs) for application in bone regeneration. The developed PROTACs (CL144 and CL174) are validated for their degradation efficiency and osteogenic effects in human BMSCs.
Sol Jeong, Jae‐Kook Cha, Wasim Ahmed, Jaewan Kim, Minsup Kim, Kyung Tae Hong, Wonji Choi, Sunjoo Choi, Tae Hyeon Yoo, Hyun‑Ju An, Seung Chan An, Jaemin Lee, Jimin Choi, Sun‐Young Kim, Jun‐Seok Lee, Soonchul Lee, Junwon Choi, Jin Man Kim   +17 more
wiley   +1 more source

Comparison of the accuracy of apex locator, digital radiography, and cone-beam computed tomography in root canal working length determination in teeth with external root resorption: An in vitro study

Dental Research Journal
Background: The aim of this study was to compare the accuracy of apex locator, digital periapical radiography, and cone-beam computed tomography (CBCT) for determining the root canal working length (WL) in teeth with external root resorption (ERR ...
Seyed Mohsen Hasheminia, Sanaz Jahadi, Farida Ghazanfari Moghaddam, Shervin Bagherieh   +3 more
doaj   +3 more sources

Y-Net for Chest X-Ray Preprocessing: Simultaneous Classification of Geometry and Segmentation of Annotations [PDF]

arXiv, 2020
Over the last decade, convolutional neural networks (CNNs) have emerged as the leading algorithms in image classification and segmentation. Recent publication of large medical imaging databases have accelerated their use in the biomedical arena. While training data for photograph classification benefits from aggressive geometric augmentation, medical ...
arxiv  

Caries detection enhancement using texture feature maps of intraoral radiographs

Oral Radiology/Springer, 2018
Dental caries are caused by tooth demineralization due to bacterial plaque formation. However, the resulting lesions are often discrete and thus barely recognizable in intraoral radiography images.
R. Obuchowicz, K. Nurzynska, B. Obuchowicz, A. Urbanik, A. Piórkowski   +4 more
semanticscholar   +1 more source

Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding

Advanced Science, EarlyView.
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen, Yuwei Zhou, Wenxiu Yuan, Yanjing Ou, Hanyu Lin, Kaixun He, Xueshen Qian, Huachen Chen, Chengchaozi Wang, Jie Lu, Weiping Chen, Dexiong Li, Jiang Chen   +12 more
wiley   +1 more source

Ultrasound‐Responsive 4D Bioscaffold for Synergistic Sonopiezoelectric‐Gaseous Osteosarcoma Therapy and Enhanced Bone Regeneration

Advanced Science, EarlyView.
An acoustic‐responsive therapeutic platform for synergistic sonopiezoelectric‐gaseous osteosarcoma therapy and bone regeneration is fabricated through the joint loading of few‐layer black phosphorus nanosheets and S‐Nitroso‐L‐glutathione onto the 3D‐printed bioactive glass scaffolds.
Haoyu Fang, Daoyu Zhu, Yixuan Chen, Changqing Zhang, Gan Li, Qihang Fang, Meiqi Chang, Yu Chen, Youshui Gao   +8 more
wiley   +1 more source

Novel nano‐hydroxyapatite coating of additively manufactured three‐dimensional porous implants improves bone ingrowth and initial fixation

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 111, Issue 2, Page 453-462, February 2023., 2023
Abstract Electron beam melting (EBM) has been used to fabricate three‐dimensional (3D) porous Ti‐6Al‐4V surfaces for acetabular cups in total hip arthroplasty. However, there are radiographic concerns regarding poor implant fixation and bone ingrowth around electron beam melted (EBMed) 3D porous cups.
Ryota Watanabe, Hiroyuki Takahashi, Aira Matsugaki, Toru Uemukai, Yasumichi Kogai, Takashi Imagama, Kiminori Yukata, Takayoshi Nakano, Takashi Sakai   +8 more
wiley   +1 more source

Synergistic Modulating of Mitochondrial Transfer and Immune Microenvironment to Attenuate Discogenic Pain

Advanced Science, EarlyView.
Gallic acid (GA) and copper ions self‐assemble to form nanoparticles, which are then modified with mitochondrial targeting peptides and gap junction modulator. These nanoparticles scavenge mitochondrial reactive oxygen species to induce M2 polarization and enhance intercellular mitochondrial transfer.
Xinzhou Wang, Zhenyu Guo, Linjie Chen, Jing Sun, Kenny Yat Hong Kwan, Morgan Jones, Yan Michael Li, Yangyang Hu, Xueqiang Wang, Pooyan Makvandi, Xiangyang Wang, Qiuping Qian, Yunlong Zhou, Aimin Wu   +13 more
wiley   +1 more source

Periodontal diagnosis and treatment planning – An assessment of the understanding of the new classification system

Journal of Dental Education, Volume 86, Issue 12, Page 1573-1580, December 2022., 2022
Abstract Objectives Substantial variations are seen among clinicians in the diagnosis and treatment planning of periodontal diseases. Accurate diagnosis and treatment planning are fundamental requirements for effective outcome‐based patient care. The aim of this study was to evaluate the understanding of the American Academy of Periodontology and the ...
Arushi Kakar, Steven Blanchard, Daniel Shin, Gerardo Maupomé, George J. Eckert, Vanchit John   +5 more
wiley   +1 more source

Performance of dual-energy subtraction in contrast-enhanced mammography for three different manufacturers: a phantom study

European Radiology Experimental
Background Dual-energy subtraction (DES) imaging is critical in contrast-enhanced mammography (CEM), as the recombination of low-energy (LE) and high-energy (HE) images produces contrast enhancement while reducing anatomical noise.
Gisella Gennaro, Giulia Vatteroni, Daniela Bernardi, Francesca Caumo   +3 more
doaj   +1 more source