Results 41 to 50 of about 73,519 (230)

On‐Paper Enzyme‐Linked and Metal‐Linked Immunosorbent Assays for Low‐Cost Decentralized Testing of Carcinoembryonic Antigen

Analysis &Sensing, EarlyView.
On‐paper enzyme‐linked and metal‐linked immunosorbent assays (p‐ELISA and p‐MeLISA, respectively) were developed for the assay of carcinoembryonic antigen (CEA) in serum. These approaches are based on bio‐conjugated paper disks as analytical platform.
Electra Mermiga, Varvara Pagkali, Dionysios Soulis, Christos Kokkinos, Anastasios Economou   +4 more
wiley   +1 more source

Benefits of Macitentan in Patients with Pulmonary Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Global Heart, 2023
Background: This systematic review and meta-analysis aimed to determine the efficacy of macitentan in patients with pulmonary hypertension (PH). Methods: A systematic search was made of PubMed, Embase, Cochrane Library, and clinicaltrials.gov, without ...
Jinlv Qin, Guizuo Wang, Dong Han
doaj   +1 more source

Machine Learning Analysis of Whole‐Blood Transcriptomics Data in Rheumatoid Arthritis Patients Treated with Adalimumab Identifies Predictive Biomarkers of Response

Arthritis &Rheumatology, Accepted Article.
Objectives Tumor necrosis factor inhibitors (TNFi) have significantly improved rheumatoid arthritis (RA) management, yet variability in patient response remains a substantial challenge, with approximately 40% of patients discontinuing TNFi due to non‐response or adverse effects. This study aimed to identify biomarkers predictive of adalimumab treatment
Chuan Fu Yap, Nisha Nair, Ann W Morgan, John D Isaacs, Anthony G Wilson, Kimme Hyrich, Guillermo Barturen, María Riva‐Torrubia, Marta Gut, Ivo Gut, Marta E. Alarcón Riquelme, Anne Barton, Darren Plant   +12 more
wiley   +1 more source

Impact of the transition from radioimmunoassay (RIA) to chemiluminescent enzyme immunoassay (CLEIA) for the measurement of plasma aldosterone concentration (PAC) on the diagnosis of primary aldosteronism (PA) via retrospective analyses in Okinawa, Japan

Endocrine Journal
In Japan, the traditional method for measuring plasma aldosterone concentration (PAC) was radioimmunoassay (RIA), which had several challenges, including poor traceability of certified reference materials and reduced detection sensitivity at low ...
Ken-ichiro Honma, Yoshiro Nakayama, Atsuko Tamaki, Moriyuki Uehara, Taiki Teruya, Takamitsu Yabiku, Yohei Ishiki, Ken Yonaha, Rei Chinen, Tsugumi Uema, Shiki Okamoto, Hiroaki Masuzaki   +11 more
doaj   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Use of the Abbott i‐STAT®1 point of care device for hCG quantification in early pregnancy

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objectives To evaluate the use of the Abbott i‐STAT®1 point‐of‐care‐test (POCT) device for measurement of human chorionic gonadotropin (hCG) to support the management of early pregnancy complications in a remote early pregnancy unit (EPU). Methods Women attending the EPU who required an hCG blood test were invited to take part in the study ...
Caroline Joyce, Paula M. O'Shea, Rebecca Lynch, Seán J. Costelloe, Tommie V. McCarthy, John Coulter, Deirdre Hayes‐Ryan, Keelin O'Donoghue   +7 more
wiley   +1 more source

Soyasaponin and vertical microbial transmission: Maternal effect on the intestinal development and health of early chicks

iMeta, EarlyView.
This study investigates the vertical transmission of maternal microbiota in chickens and how it is modulated by maternal soyasaponin supplementation. Using a model spanning the reproductive tract, egg components, and developing chicks, we show that maternal gut and reproductive microbiota, including Bifidobacterium adolescentis (B.
Mingkun Gao, Shu Chen, Hao Fan, Peng Li, Aiqiao Liu, Dongli Li, Xiaomin Li, Yongfei Hu, Guofeng Han, Yuming Guo, Zengpeng Lv   +10 more
wiley   +1 more source

Corticosterone and Mitochondrial Efficiency Are Associated With Changes in DNA Oxidative Damage During an Acute Stress Response in Leach's Storm‐Petrels (Hydrobates leucorhous)

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT The ability of organisms to effectively respond to challenges is critical for survival. We investigated how an acute stressor affected corticosterone, mitochondrial function, and DNA oxidative damage in a wild population of Leach's storm‐petrels (Hydrobates leucorhous).
Kayla E. Lichtner, Jack K. Dziubek, Nicole A. Joseph, Sarah E. Chapman, Tori J. Chace, Dongxiao Sun, Zachary T. Bitzer, Antoine Stier, Robert A. Mauck, Patricia L. Jones, Mark F. Haussmann   +10 more
wiley   +1 more source

Metabolic clearance rate of insulin across the glucose tolerance spectrum by race and ethnicity in youth with obesity

Obesity, EarlyView.
Abstract Objective Despite β‐cell failure in youth with dysglycemia (i.e., impaired glucose tolerance [IGT] and type 2 diabetes), fasting insulin (FI) concentrations are elevated. Herein, we examined the following: 1) metabolic clearance rate of insulin (MCRI) in youth with obesity and normal glucose tolerance (NGT) versus those with IGT versus those ...
Wonhee Cho, Fida Bacha, Hala Tfayli, SoJung Lee, Sara F. Michaliszyn, Joon Young Kim, Silva Arslanian   +6 more
wiley   +1 more source

Assessing cortisol concentration in different matrices: predictive potential and relationship with production levels, lactation stage and parity in dairy buffaloes

Italian Journal of Animal Science
Cortisol is the primary biomarker associated with the hypothalamic–pituitary–adrenal (HPA) axis. This research aimed at assessing the predictive potential and the relationship of cortisol concentrations in four media (blood, milk, whey and hair) with ...
Alessio Cotticelli, Giovanna Bifulco, Isabella Pividori, Roberta Matera, Maria Teresa Verde, Matteo Santinello, Alberto Prandi, Tanja Peric   +7 more
doaj   +1 more source