Results 201 to 210 of about 87,481 (331)

Pharmacokinetic Characterization of Single-Stranded DNA in Murine Models Using High-Specific-Activity ⁶⁸Ga Radiolabeling Coupled with Dynamic Positron Emission Tomography. [PDF]

ACS Omega
Li P, Wang H, Huang Z, Li Y, Li M, Jiang D, Li J.   +6 more
europepmc   +1 more source

NUDIX hydrolases target specific inositol pyrophosphates and regulate phosphate homeostasis and bacterial pathogen susceptibility in Arabidopsis

Journal of Integrative Plant Biology, EarlyView.
NUDIX‐type hydrolase enzymes of subclade I and II preferentially target the inositol pyrophosphate messengers 4‐ and 3‐InsP7, respectively. Inactivation of subclade II NUDTs disrupts phosphate homeostasis and enhances bacterial resistance, revealing connections between defense and nutrient signaling.
Robin Schneider, Klea Lami, Isabel Prucker, Sara Christina Stolze, Annett Strauß, Julie Marie Schmidt, Simon M. Bartsch, Kevin Langenbach, Esther Lange, Kevin Ritter, David Furkert, Natalie Faiß, Sandeep Kumar, M. Shamim Hasan, Athanasios Makris, Lukas Krusenbaum, Stefanie Wege, Yemisrach Zewdu Belay, Simon Kriescher, Jeremy The, Michael Harings, Florian M. W. Grundler, Martina K. Ried‐Lasi, Heiko Schoof, Philipp Gaugler, Marília Kamleitner, Dorothea Fiedler, Hirofumi Nakagami, Ricardo F. H. Giehl, Thomas Lahaye, Saikat Bhattacharjee, Henning J. Jessen, Verena Gaugler, Gabriel Schaaf   +33 more
wiley   +1 more source

Optimization of the radiosynthesis of the PSMA-targeting drugs [¹⁷⁷Lu]Lu-P17-087 and [¹⁷⁷Lu]Lu-P17-088 on the MiniLu™ automated module. [PDF]

EJNMMI Radiopharm Chem
Alexoff D, Ploessl K, Zhao R, Li L, Kim D, Zhu L, Kung H.   +6 more
europepmc   +1 more source

Additional file 2 of Radiolabeling of Angiostrongylus vasorum- and Crenosoma striatum larvae: a novel method using PET/CT to unveil larval migration in the gastropod intermediate host (Lissachatina fulica)

van de Sanden, Joep T., Dusch, Alena, Westhoff, Katharina M., Bernsen, Monique R., Taubert, Anja, Hermosilla Carlos, Verburg Frederik A   +6 more
openalex   +1 more source

Systematic review and meta‐analysis of the efficacy and safety of [177Lu]Lu‐edotreotide ([177Lu]Lu‐DOTATOC) for the treatment of neuroendocrine tumors

Journal of Neuroendocrinology, EarlyView.
Abstract [177Lu]Lu‐edotreotide is a radiopharmaceutical therapy (RPT) targeting somatostatin receptors, which are commonly overexpressed on neuroendocrine tumors (NETs). This systematic literature review and meta‐analysis describes the efficacy and safety of [177Lu]Lu‐edotreotide in patients with NETs.
Richard P. Baum, Julia G. Fricke, Tristan Ruhwedel, Holger Amthauer, Erika Patricia Azorin‐Vega, Dieter Hörsch, Riccardo Laudicella, Vikalp Maheshwari, Martin A. Walter, Berna Degirmenci Polack, Simon F. Spiegl, Guillaume P. Nicolas   +11 more
wiley   +1 more source

Side by side comparison of NOTA and DOTA for conjugation efficiency, gallium-68 labeling, and in vivo biodistribution of anti-mesothelin sdAb A1-His. [PDF]

EJNMMI Radiopharm Chem
N'Guessan É, Bacot S, Raes F, Leenhardt J, Guenard T, Dumas L, Ghezzi C, Fagret D, Lombardi C, Broisat A, Ahmadi M.   +10 more
europepmc   +1 more source

Pharmacokinetics, metabolism, excretion and safety of iruplinalkib (WX-0593), a novel ALK inhibitor, in healthy subjects: a phase I human radiolabeled mass balance study

Yicong Bian, Sheng Ma, Qingqing Yao, Tao Hu, Mingjing Ge, Hongting Li, Shansong Zheng, Zhe-ming Gu, Hao Feng, Zhenwen Yu, Chenrong Huang, Hua Zhang, Limei Zhao, Liyan Miao   +13 more
openalex   +1 more source

Comparison of Human and Canine P‐Glycoprotein Substrates at R, P, and H Binding Sites

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT P‐glycoprotein (P‐gp) greatly impacts substrate drug disposition, so much so that regulatory agencies recommend ascertaining the P‐gp status of active pharmaceutical ingredients (APIs) intended for human use. Arguably, the P‐gp status of drugs intended for canine patients is equally, if not more, important.
Neal S. Burke, Katrina L. Mealey
wiley   +1 more source

Relationship Between Intragastric Meal Distribution, Gastric Emptying, and Gastric Neuromuscular Dysfunction in Chronic Gastroduodenal Disorders

Neurogastroenterology &Motility, EarlyView.
Multimodal physiological testing using gastric emptying scintigraphy with intragastric meal distribution and body surface gastric mapping showed proximal retention of food correlated with delayed emptying and neuromuscular spectral abnormalities (abnormal slow wave frequencies or rhythms) and delayed motility responses on BSGM.
Chris Varghese, Armen A. Gharibans, Daphne Foong, Gabriel Schamberg, Stefan Calder, Vincent Ho, Reena Anand, Christopher N. Andrews, Alan H. Maurer, Thomas Abell, Henry P. Parkman, Greg O'Grady   +11 more
wiley   +1 more source

Specific reaction conditions for efficient automated ⁶⁸Ga-radiolabeling of the FAP-2286 pseudopeptide on a GAIA^® synthesizer. [PDF]

Front Med (Lausanne)
Ammour M, Torchio J, Renaud SC, Rubira L, Fersing C.   +4 more
europepmc   +1 more source