Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
<sup>177</sup>Lu-Labeled Magnetic Nano-Formulations: Synthesis, Radio- and Physico-Chemical Characterization, Biological Applications, Current Challenges, and Future Perspectives. [PDF]
Halevas E, Varna D.
europepmc +1 more source
Vacuolar transport and function of Saccharomyces cerevisiae sterol ester hydrolase Tgl1
Tgl1, one of yeast sterol ester hydrolases, had been found on the lipid droplets where sterol esters are mainly stored. This study revealed that Tgl1 is transported into the vacuole depending on the ESCRT‐I–III complex, and that it exhibits intra‐vacuolar sterol ester hydrolase activity.
Takumi Nakatsuji +5 more
wiley +1 more source
Radiolabeling of CHX-A″-DTPA-Antibody Conjugates with [<sup>89</sup>Zr]ZrCl<sub>4</sub>. [PDF]
Lyashchenko SK +8 more
europepmc +1 more source
The IQ‐compete assay for measuring mitochondrial protein import efficiencies in living yeast cells
The efficiency of mitochondrial protein import depends on the properties of the newly synthesized precursor proteins. The Import and de‐Quenching Competition (IQ‐compete) assay is a novel method to monitor the import efficiency of different proteins by fluorescence in living yeast cells.
Yasmin Hoffman +3 more
wiley +1 more source
Versatile Bifunctional PYTA Derivatives for <sup>225</sup>Ac Radiolabeling: A Comparison to Gold Standards. [PDF]
Cheveau M +8 more
europepmc +1 more source
Automated radiolabeling and handling of 177Lu‐ and 225Ac‐PSMA‐617 using a robotic pipettor [PDF]
Shin Hye Ahn, Anthony P. Belanger
openalex +1 more source
Radiolabeled Phosphonium Salts as Mitochondrial Voltage Sensors for Positron Emission Tomography Myocardial Imaging Agents [PDF]
Dong-Yeon Kim, Jung‐Joon Min
openalex +1 more source
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová +11 more
wiley +1 more source

