Results 291 to 300 of about 87,481 (331)

Correlating membrane‐protein dynamics with function: Integrating bioinformatics, molecular dynamics, and single‐molecule FRET

Protein Science, Volume 34, Issue 11, November 2025.
Abstract We present a strategy that deploys structural bioinformatics, molecular simulation, and single‐molecule Förster Resonance Energy Transfer (FRET) microscopy for observing the ligand‐dependent conformational dynamics of integral membrane proteins in situ.
Hugh R. Higinbotham, Christine A. Arbour, Barbara Imperiali   +2 more
wiley   +1 more source

Pharmaceutical Applications of Metal Complexes and Derived Materials. [PDF]

Pharmaceutics
Maia PIDS.
europepmc   +1 more source

Multidimensional Evaluation of Lisdexamfetamine: Pharmacology, Therapeutic Use, Toxicity and Forensic Implications

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 5, November 2025.
Structure of lisdexamfetamine dimesylate, its active metabolite d‐amphetamine and the essential amino acid l‐lysine, along with the mechanism of action and primary pharmacological and adverse effects associated with lisdexamfetamine dimesylate. TAAR1, trace amine‐associated receptor; VMAT, vesicular monoamine transporter; DAT, dopamine transporter; NAT,
Mariana Silva‐Carvalho, Daniel José Barbosa, Diana Dias da Silva, Ricardo Jorge Dinis‐Oliveira   +3 more
wiley   +1 more source

Exploring In Vivo Metal Chelation as an Approach for Pretargeted PET Imaging. [PDF]

ACS Omega
Mishra A, Keeling G, Kim J, T M de Rosales R.   +3 more
europepmc   +1 more source

Mass Balance and Metabolism of 14C‐Atogepant in Healthy Male Participants: Findings of a Phase 1 Clinical Trial

Clinical and Translational Science, Volume 18, Issue 11, November 2025.
ABSTRACT Atogepant, a calcitonin gene‐related peptide (CGRP) receptor antagonist, is approved for the preventive treatment of migraine in adults. This open‐label, phase 1 study examined radiolabeled atogepant (14C‐atogepant) metabolism, elimination, and mass balance after a single dose (50 mg, ~200 μCi) in healthy adult males.
Ramesh R. Boinpally, Pushpa Chandrasekar, Joshua M. Rowe   +2 more
wiley   +1 more source

From radiolabeling to receptor quantification: preclinical assessment of [^99mTc]Tc-carvedilol as a cardiac β-adrenoceptor probe. [PDF]

Front Pharmacol
Azhari HF.
europepmc   +1 more source

A Phase 1 Study to Assess the Effect of Fruquintinib on the Pharmacokinetics of P‐gp and BCRP Substrates in Healthy Subjects

Clinical and Translational Science, Volume 18, Issue 11, November 2025.
ABSTRACT Fruquintinib, a highly selective, oral inhibitor of all three vascular endothelial growth factor receptors (−1, −2, and −3), is approved for previously treated metastatic colorectal cancer. This phase 1, two‐part, two‐period, fixed‐sequence study (NCT05368805) evaluated the potential inhibitory effect of fruquintinib (5 mg) on the ...
Martha Gonzalez, Zhao Yang, William R. Schelman, Xiaofei Zhou, Neeraj Gupta, Caly Chien   +5 more
wiley   +1 more source

Using the PET/CT radiotracer [⁶⁸Ga]Ga-DOTA-mDesmo to target V1b receptors and localize corticotropinoma in Cushing's disease. [PDF]

Commun Med (Lond)
Pandey S, Walia R, Kaur G, Pandav K, Rather I, Rana N, Sahoo S, Mittal BR, Shukla J.   +8 more
europepmc   +1 more source

A somatic multiple myeloma mutation unravels a mechanism of oligomerization‐mediated product inhibition in GGPPS

The FEBS Journal, Volume 292, Issue 21, Page 5802-5817, November 2025.
Geranylgeranyl diphosphate synthase (GGPPS) plays a key role in multiple myeloma biology. Using crystallography, mass spectrometry, and fluorescence spectroscopy, this study shows that a somatic multiple myeloma cell line mutation destabilizes inter‐dimer interactions, resulting in increased GGPPS activity by facilitating product releas.
Ruba Yehia, Jasmína Mária Portašiková, Rut Mor Yosef, Benny Da'adoosh, Alan Kádek, Petr Man, Moshe Giladi, Yoni Haitin   +7 more
wiley   +1 more source

Cation Exchange Protocol to Radiolabel Rare-Earth Nanoparticles with Yttrium-90 for Radiotherapy and for Magnetic Resonance Imaging. [PDF]

ACS Appl Mater Interfaces
Soni N, Panaite AM, Samanta T, Nucci GEP, Rodrigues EM, Pellegrino T.   +5 more
europepmc   +1 more source