Results 301 to 310 of about 88,244 (379)

From Radiocopper to Cold Copper: Mechanistic Modeling and Simulation to Define Clinical Response Criteria and Biomarkers for VTX‐801 in Wilson Disease

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 1, January 2026.
ABSTRACT We developed a comprehensive, mechanistic model of human copper metabolism to support biomarker qualification for VTX‐801, an adeno‐associated vector‐based gene therapy which is being developed to restore the mutated ATP7B copper transporter gene in Wilson disease (WD). The model integrates physiological copper kinetics with pathophysiological
Andreas Lindauer, Bernard Benichou, Gloria González Aseguinolaza, Jean‐Philippe Combal   +3 more
wiley   +1 more source

Radiolabeled Nanogels: From Multimodality Imaging to Combination Therapy of Cancer. [PDF]

Small Sci
Ghosh S, Cai W, Chakravarty R.
europepmc   +1 more source

Interleukin‐8 Overexpressing Collagen Microgel‐Based Cellular Microtissue Accelerates the Healing of Diabetic Foot Ulcers

Small, Volume 22, Issue 3, 13 January 2026.
Collagen microgels (CMGs) incubated with cells self‐assemble into CMG‐based cellular microtissues (CCMs), enhancing cell adhesion and upregulating IL‐8 expression. A combinatorial strategy that integrates the CMG platform with IL‐8 overexpression promotes cell proliferation, migration, angiogenesis, and survival, thereby accelerating diabetic wound ...
Haeun Chung, Won Young Jang, Jung‐Kyun Choi, Sang‐Heon Kim   +3 more
wiley   +1 more source

N-Heterocyclic Carbenes as Ligands to ¹⁹⁸Au(I)-Radiolabeled Compounds: A New Platform for Radiopharmaceutical Design. [PDF]

J Med Chem
Spreckelmeyer S, Thomas SR, Schuderer F, Pinto CIG, de Andrade Querino AL, Böhm FA, Park M, Geppert C, Gorges C, Mendes F, Casini A.   +10 more
europepmc   +1 more source

Hydrogel Microspheres for Biomedical Applications

Small Science, Volume 6, Issue 1, January 2026.
Hydrogel microspheres (HMs) play pivotal roles in biomedical applications, such as drug delivery, cell culture, regenerative medicine, wound healing, and tumor immunity. This review focuses on the latest findings to provide a more comprehensive understanding of HMs for biomedical applications.
Yingkang Huang, Xi Zhu, Jinhong Zhou, Henan Li, Wei Zhang, Danyang Shen, Ziyan Huang, Tianbo Zhang, Lin Zhuang, Lei Qin, Xiaofeng Xue, Yunjie Lu   +11 more
wiley   +1 more source

Ga-68-Labeled Affibody Molecule-Based Radiopharmaceutical Targeting Platelet Derived Growth Factor Receptor Beta for Detection of Active Fibrosis in Patients with Myocardial Infarction. [PDF]

Pharmaceuticals (Basel)
Velikyan I, Grinnemo KH, Flodin V, James S, Thelander U, Wagner M, Rodin S, Kero T, Korsgren O, Eriksson O.   +9 more
europepmc   +1 more source

Increased ATP production and P‐glycoprotein activity underlie the marked changes in blood–brain barrier transport of drugs in a mouse model of amyotrophic lateral sclerosis

British Journal of Pharmacology, Volume 183, Issue 2, Page 280-295, January 2026.
Background and purpose Patients with amyotrophic lateral sclerosis (ALS) are prescribed many medications for symptomatic relief. However, how potential alterations to the blood–brain barrier (BBB) affect the brain exposure of drugs in ALS remains under‐investigated. Experimental approach We used high‐dimensional proteomic analysis, cellular metabolism,
Yijun Pan, Alanna G. Spiteri, Pranav Runwal, Jiaqi Sun, Dana S. Hutchinson, Yoshiteru Kagawa, Bradley J. Turner, Cheng Huang, Anup D. Shah, Ralf B. Schittenhelm, Joseph A. Nicolazzo   +10 more
wiley   +1 more source

Copper-mediated radiochemistry: historical impact, current trends, and future possibilities. [PDF]

Npj Imaging
Bowden GD, Müller M, Herth MM, Sanford MS, Scott PJH.   +4 more
europepmc   +1 more source

Enhanced Radionuclide Therapy via the Conjugation of Pentadecanoic Acids With 225Ac‐ and 177Lu‐Labeled RGD Peptides

Cancer Science, Volume 117, Issue 1, Page 193-202, January 2026.
Radionuclide therapy using PD‐K(225Ac‐DOTA)‐RGD in BxPC‐3‐bearing mice. PD‐K(225Ac‐DOTA)‐RGD successfully suppressed tumor growth. ABSTRACT Improved peptide pharmacokinetics are needed to enhance the therapeutic effects of peptide‐based radionuclide therapy.
Mitsuyoshi Yoshimoto, Shun‐ichi Wada, Yukie Yoshii, Sayaka Hanadate, Anri Inaki, Hirofumi Fujii   +5 more
wiley   +1 more source

Redefining AT1 Receptor PET Imaging: Introducing the Radiotracer [¹⁸F]DR29. [PDF]

Hypertension
Chen X, Kimura H, Sasaki T, Klimek K, Mühlig S, Arias-Loza AP, Nose N, Yagi Y, Rowe SP, Lapa C, Werner RA, Higuchi T.   +11 more
europepmc   +1 more source