Results 71 to 80 of about 2,283,209 (217)
Immunofunctional assay of human growth hormone (hGH) in serum: A possible consensus for quantitative hGH measurement [PDF]
, 1996 Confirmation of the diagnosis of GH deficiency in adults and children involves provocative testing for human (h) GH. Different commercially available immunoassays yield largely discrepant results in the measurement of GH levels in human serum.
Strasburger, Christian J. +3 more
core +1 more source
Pharmacology Research &Perspectives, Volume 14, Issue 6, December 2026.ABSTRACT Clinically used analgesics such as gabapentinoids and opioids have limited efficacy and adverse effects like abuse liability, and there is a dire need for novel analgesics with improved safety profiles. Since lysophosphatidic acid can induce neuropathic pain in rodents, LPA receptor antagonists have been investigated as potential analgesics ...
Kristen L. Woodhouse +6 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 23, Page 6767-6786, December 2026.Abstract Background and Purpose Radiprodil is a GluN2B subunit selective NMDA receptor negative allosteric modulator which is currently under clinical investigation as a possible anti‐epileptic drug for paediatric use. Our goal was to investigate the inhibition of dopaminergic neuron NMDA responses by radiprodil.
Bangyuan Liu, Alasdair J. Gibb
wiley +1 more source
Clinical Chemistry, 1990 Abstract Although experimental evidence indicates a probable role of epidermal growth factor receptor (EGFr) in clinical oncology, no standardized method for its determination has been yet described, and discrepant results have been reported in clinical studies.
R, Dittadi +3 more
openaire +2 more sources
In vitro Radioligand Competition Binding Assay.
, 2013 Ligand binding affinity (pIC50) were measured on intact COS-7 cells transfected with wild type and mutant receptors by competition binding using 125I-His5-D-Tyr6-GnRH1.Bmax = % of total radioligand bound were expressed relative to wild type receptor ...
Javier A. Tello (320277) +5 more
core +1 more source
Molecules, 2018 Natural products are an abundant source of potential drugs, and their diversity makes them a rich and viable prospective source of bioactive cannabinoid ligands.
Pankaj Pandey +10 more
doaj +1 more source
Advanced Healthcare Materials, Volume 15, Issue 41, 6 November 2026.Prostate patient‐derived organoids (PDOs) were established from TURP and biopsy specimens with >90% success and retain key features of their tissues of origin, making them functional avatars for antisense oligonucleotide (ASO) therapy . Transfecting single cells outside the Matrigel matrix and then reconstituting organoids overcomes the 3D delivery ...
Thi Thom Tran +15 more
wiley +1 more source
Summary concentration-response curves for radioligand binding.
, 2019 Competition radioligand binding was performed as described in the Materials and Methods for all 9 clinical opioids and a positive control competitor ligand at all 9 receptor targets. Positive control: MOR/DOR/KOR = naloxone, NOP = nociceptin, CB1 = WIN55,
Daniel Womer (6807767) +4 more
core +1 more source
Receptor Binding Techniques [PDF]
, 1997 This overview first discusses issues relating to the selection of radioligand for receptor binding assays, including the isotopic label and considerations pertaining to the pharmacological and chemical profile of the ligand. This is followed by a section
Frey, Kirk A. +3 more
core +1 more source
Pharmaceuticals, 2020 Muscarinic acetylcholine receptors (mAChRs) are a pivotal constituent of the central and peripheral nervous system. Yet, therapeutic and diagnostic applications thereof are hampered by the lack of subtype selective ligands.
Marius Ozenil +8 more
doaj +1 more source