Results 71 to 80 of about 19,808 (220)

Erarbeitung eines optimalen Aufnahmemodus zur dynamischen Bildgebung an einem Kleintier-Einzelphotonen-Emissionstomographie-Gerät und Etablierung von Normwerten bei der Nieren- und Speicheldrüsenfunktionsszintigraphie bei der Maus [PDF]

, 2019
Ziel: Ziel dieser Studien ist erstens die Ermittlung eines optimierten standardisierten Untersuchungsalgorithmus in der Multi-Pinhole Einzelphotonen-Emissionscomputertomographie (SPECT) für die dreidimensionale Nierenfunktions- und ...
Huang, Kai
core   +1 more source

Focusing on Prostate-Specific Membrane Antigen in Precision Diagnosis and Treatment of Prostate Cancer

Biomedicines
Prostate cancer (PCa) is the most common malignant tumor of the male genitourinary system, and its incidence and mortality have shown a marked global increase in recent years.
Xinyi Ren, Lingling Zhang, Ran An, Hongchen Song, Mingjun Shi, Zhenchang Wang   +5 more
doaj   +1 more source

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, EarlyView.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source

[18F]DPA-714 as a biomarker for positron emission tomography imaging of rheumatoid arthritis in an animal model. [PDF]

, 2014
International audienceINTRODUCTION: Rheumatoid arthritis (RA) is a chronic disease, affecting 0.5-1% of adults in industrialized countries, in which systemic inflammation and synovitis drive joint destruction.
Bernards, Nicholas, Boisgard, Raphael, Dollé, Frédéric, Pottier, Géraldine   +3 more
core   +4 more sources

Elevated FDG uptake in non-tumorous lung regions does not predict immune checkpoint inhibitor–related pneumonitis in lung cancer patients

Frontiers in Oncology
BackgroundPredictors for checkpoint inhibitor-related pneumonitis (cinrPneumonitis) are desperately needed. This study aimed to investigate the pretreatment standardized uptake value (SUV) on [18F]FDG-PET/CT of non-tumorous lung tissue as a predictive ...
Friederike Völter, Friederike Völter, Friederike Völter, Lukas Wehlte, Blerina Resuli, Blerina Resuli, Blerina Resuli, Julia Walter, Julia Walter, Julia Walter, Lea Daisenberger, Maria Ingenerf, Maurice Heimer, Matthias Brendel, Matthias Brendel, Matthias Brendel, Gabriel T. Sheikh, Lena M. Unterrainer, Lena M. Unterrainer, Lena M. Unterrainer, Diego Kauffmann-Guerrero, Diego Kauffmann-Guerrero, Diego Kauffmann-Guerrero, Thomas Pfluger, Lucie Heinzerling, Lucie Heinzerling, Amanda Tufman, Amanda Tufman, Amanda Tufman   +28 more
doaj   +1 more source

PSMA Theranostics: Current Status and Future Directions

Molecular Imaging, 2018
Prostate-specific membrane antigen (PSMA) is a promising target for imaging diagnostics and targeted radionuclide therapy (theranostics) of prostate cancer and its metastases.
Kambiz Rahbar MD, Ali Afshar-Oromieh MD, Hossein Jadvar MD, PhD, Hojjat Ahmadzadehfar MD, MSc   +3 more
doaj   +1 more source

Evidence that 5‐HT2A receptor signalling efficacy and not biased agonism differentiates serotonergic psychedelic from non‐psychedelic drugs

British Journal of Pharmacology, EarlyView.
Background and Purpose Serotonergic psychedelic drugs are under investigation as therapies for various psychiatric disorders, including major depression. Although serotonergic psychedelic drugs are 5‐HT2A receptor agonists, some such agonists are not psychedelic, potentially due to differences in 5‐HT2A receptor ligand bias or signalling efficacy. Here,
Aurelija Ippolito, Sridhar Vasudevan, Shaun Hurley, Gary Gilmour, Frederick Westhorpe, Grant Churchill, Trevor Sharp   +6 more
wiley   +1 more source

Metal ion-dependent biological properties of a chelator-derivatised somatostatin analogue for tumour targeting [PDF]

, 2008
A publicar na Revista Chemistry a European JournalSomatostatin-based radioligands were shown to have sensitive imaging properties for neuroendocrine tumours and their metastases.
Antunes, Behr, Bertini, Blower, de Jong, de Jong, De Reuck, Froidevaux, Ginj, Ginj, Ginj, Golub, Henze, Heppeler, Jansen, Korf, Kwekkeboom, Kwekkeboom, Liu, Maecke, Maecke, Okarvi, Reubi, Reubi, Reubi, Riesen, Ruser, Sheldrick, Smith, Stevens, Szabo, Weiner, Zhernosekov, Zuberbuehler   +33 more
core   +1 more source

Divergence in μ and δ opioid receptor pharmacology in neurons and antinociceptive efficacy in neuropathic pain: Insights from MP135 and CYM51010

British Journal of Pharmacology, EarlyView.
Background and purpose Opioids targeting the μ opioid receptor remain largely ineffective in neuropathic pain conditions, emphasizing the need for novel therapeutic strategies. MP135 was reported to reduce thermal nociception in naive animals by activating μ‐δ opioid receptor heteromers.
Perrine Inquimbert, Chantal Fitterer, Sylvain Hugel, Mila Jesic, Yannick Goumon, Virgine Andry, Severine Schneider, Francois Daubeuf, Abdelfattah Faouzi, Stephane Doridot, Susruta Majumdar, Frederic Bihel, Martine Schmitt, Dominique Massotte   +13 more
wiley   +1 more source

Pepducin-mediated cardioprotection via β-arrestin-biased β2-adrenergic receptor-specific signaling [PDF]

, 2018
Reperfusion as a therapeutic intervention for acute myocardial infarction-induced cardiac injury itself induces further cardiomyocyte death. β-arrestin (βarr)-biased β-adrenergic receptor (βAR) activation promotes survival signaling responses in vitro ...
Benovic, Jeffrey L., Carter, Rhonda L., de Lucia, Claudio, Gao, Erhe, Grisanti, Laurel A., Koch, Walter J., Thomas, Toby P., Tilley, Douglas G.   +7 more
core   +1 more source