Results 111 to 120 of about 333 (138)
Bulletin of Experimental Biology and Medicine, 2017 The therapeutic radiomitigating effect of cystamine and indralin was studied in experiments on mice and rats and pharmacological analysis of these drugs was carried out. The animals were subjected to whole-body 60Co γ-irradiation. The mice were exposed to single (9-10 Gy) or double (8 Gy) irradiation with an interval of 1 month.
A A Galkin, I B Ushakov, M V Vasin
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Study of the Potential Radiomitigator Effect of Quercetin on Human Lymphocytes
Inflammation, 2018Several substances of synthetic and natural origin have been studied to determine their ability to protect the body from damage caused by ionizing radiation. Among these substances, quercetin has been shown to be a naturally occurring molecule with high radioprotective and radiomitigator potential due to its antioxidant properties.
Williams Nascimento de Siqueira +11 more
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Preclinical pharmacokinetics of the radiomitigator KZ-41 in rats
Xenobiotica, 2011KZ-41, a quinic acid derivative, significantly reduces mortality in a murine model of hematopoietic acute radiation syndrome. The purpose of this study was to evaluate the systemic pharmacokinetics, elimination, and oral bioavailability of KZ-41 in rats.
Kui, Zeng +4 more
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Radioprotectors and Radiomitigators for Improving Radiation Therapy: The Small Business Innovation Research (SBIR) Gateway for Accelerating Clinical Translation. [PDF]
Radiation Research, 2015 Although radiation therapy is an important cancer treatment modality, patients may experience adverse effects. The use of a radiation-effect modulator may help improve the outcome and health-related quality of life (HRQOL) of patients undergoing radiation therapy either by enhancing tumor cell killing or by protecting normal tissues.
Pataje G S Prasanna +2 more
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Technology in Cancer Research and Treatment, 2012 Due to radiation-induced immune depression and development of pathologies such as cancer, there is increasing urgency to identify radiomitigators that are effective when administered after radiation exposure. The main goal of this study was to determine the radiomitigation capacity of MnTE-2-PyP[Mn(III) tetrakis (N-ethylpyridinium-2-yl) porphyrin], a ...
Michael J Pecaut, J M Slater
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STUDY OF RADIOMITIGATOR PROPERTIES OF MYOTIVE
XI Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов, молекулярных биологов и специалистов фундаментальной медицины — 2024 : сб. тез.It is known that NMR spectroscopy can be effectively used to detect metabolic changes in the blood and urine caused by partial and total body irradiation [1]. The purpose of our work was to study changes in the composition of metabolites of erythrocytes by NMR spectroscopy after administration of the drug MYOTIVE to rats irradiated with γ-radiation at ...
A.S. Bykov +7 more
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The AAPS Journal, 2017
TP508 is a synthetically derived tissue repair peptide that has previously demonstrated safety and potential efficacy in phase I/II clinical trials for the treatment of diabetic foot ulcers. Recent studies show that a single injection of TP508 administered 24 h after irradiation significantly increases survival and delays mortality in murine models of ...
Scott D, McVicar +2 more
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TP508 is a synthetically derived tissue repair peptide that has previously demonstrated safety and potential efficacy in phase I/II clinical trials for the treatment of diabetic foot ulcers. Recent studies show that a single injection of TP508 administered 24 h after irradiation significantly increases survival and delays mortality in murine models of ...
Scott D, McVicar +2 more
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Drug Development Research, 2013
Abstract Preclinical Research Acute radiation syndrome is induced when a significant portion of the body receives high‐dose, as well as high‐dose rate, radiation. We have previously identified a quinic acid‐based derivative, KZ‐41, that protects from radiation injury.
Karin E, Thompson +5 more
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Abstract Preclinical Research Acute radiation syndrome is induced when a significant portion of the body receives high‐dose, as well as high‐dose rate, radiation. We have previously identified a quinic acid‐based derivative, KZ‐41, that protects from radiation injury.
Karin E, Thompson +5 more
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[Radiomitigators: prospects for use in medical radiation protection].
Voenno-meditsinskii zhurnal, 2014Prospects of creation and use of radiomitigators--the treatment-and-prophylactic means intended for rendering medical care by the victim of influence of ionizing radiation in the earliest terms after irradiation (hours, days) are presented. It is shown that the most effective radiomitigators are found among natural biopolymers of a microbic origin (a ...
A N, Grebeniuk +2 more
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International Journal of Radiation Biology
The acute radiation syndrome (ARS) represents a significant public health threat following nuclear exposure, with limited available medical countermeasures (MCMs). Imidazolyl ethanamide pentandioic acid (IEPA), a novel orally bioavailable small molecule, has demonstrated radioprotective effects in rodent models earlier.
Radoslaw Wesolowski +4 more
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The acute radiation syndrome (ARS) represents a significant public health threat following nuclear exposure, with limited available medical countermeasures (MCMs). Imidazolyl ethanamide pentandioic acid (IEPA), a novel orally bioavailable small molecule, has demonstrated radioprotective effects in rodent models earlier.
Radoslaw Wesolowski +4 more
openaire +2 more sources