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Molecular Insights Into Radiation Effects and Protective Mechanisms: A Focus on Cellular Damage and Radioprotectors [PDF]
Current Issues in Molecular BiologyIonizing radiation has been a critical tool in various fields, such as medicine, agriculture, and energy production, since its discovery in 1895. While its applications—particularly in cancer treatment and diagnostics—offer significant benefits, ionizing
Ana Melero +2 more
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Nitroxides: Chemistry, Antioxidant Properties, and Biomedical Applications [PDF]
MoleculesNitroxides are stable organic free radicals with a wide range of applications. They have found applications in chemistry, biochemistry, biophysics, molecular biology, and biomedicine as EPR/NMR imaging techniques. As spin labels and probes, they are used
Krzysztof Gwozdzinski +2 more
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A Systematic Organization of Bioinformatics Database of Radiosensitizers and Radioprotectors
Journal of Radiation and Cancer Research, 2018 Radiosensitizers and radioprotectors are the compounds that modify the radiation therapy treatment. Radiosensitizers make tumor cell more sensitive to radiation therapy which increases the effectiveness of cancer treatment, whereas radioprotectors are ...
P M Dongre
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Different Effects of Antioxidants Against Ionizing Radiation: An Experimental Model of Micronuclei [PDF]
Current Issues in Molecular BiologyThere is an urgent need to find and develop radiation countermeasures for both planned and unplanned exposures. However, in recent years, radioprotective substances, such as rosmarinic acid (RA), have been described, presenting contradictory and even ...
Miguel Alcaraz +7 more
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Radiosensitizers, Radioprotectors, and Radiation Mitigators.
Indian Journal of Dental Research, 2014 Radiotherapy is regarded as one of the most important therapeutic modality for the treatment of malignant lesions. This field is undergoing rapid advancements in the recent times. With the use of radiosensitizers and radioprotective agents, the course of
Venkata Suneel Kumar
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Radioprotective Effect of α-Tocotrienol on Radiation-Induced Brain Injury in Rats [PDF]
Journal of Biomedical Physics and EngineeringBackground: In medicine, ionizing radiation can damage cells by generating free radicals, harming healthy tissues during radiotherapy. Radioprotectors help mitigate this damage, but current options often have low efficacy, high cost, or side effects ...
Karim Ghazikhanlou Sani +3 more
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Reposition of lenalidomide as a radiation protector based on LINCS gene expression signatures and its preclinical validation [PDF]
Scientific ReportsIonizing radiation induces DNA damage and impairs genomic integrity, leading to cell death and tissue injuries or carcinogenesis. Medical radiation protectors are essential and necessary. However, there are limited radioprotectors in clinics, which can’t
Qi Huang +6 more
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Antioxidants, 2021 In radiation oncology, the modulation of the bystander effect is a target both for the destruction of tumor cells and to protect healthy cells. With this objective, we determine whether the radioprotective capacity of rosmarinic acid (RA) can affect the ...
Amparo Olivares +4 more
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Biomolecules, 2023 The radiation protection strategy with chemical agents has long been based on an antioxidative approach consisting in reducing the number of radical oxygen and nitrogen species responsible for the formation of the radiation-induced (RI) DNA damage ...
Juliette Restier-Verlet +10 more
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Разработка и регистрация лекарственных средств, 2023 Introduction. The use of radiopharmaceuticals for targeted radionuclide therapy (TRT), the efficacy of which was established during clinical trials, is safe and effective for various pathological conditions, including cancer.
E. P. Pavlenko +2 more
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