Results 11 to 20 of about 2,043 (197)

Chemical Radioprotectors [PDF]

Defence Science Journal, 2005
Protection of biological systems against radiation damage is of paramount importance during accidental and unavoidable exposure to radiation. Several physico-chemical and biological factors collectively contribute to the damage caused by radiation and ...
S. N. Upadhyay, B. S. Dwarakanath, T. Ravindranath, T. L. Mathew   +3 more
openaire   +2 more sources

Experimental model for assessing the effectiveness of radioprotectors in biomedical research

Acta Biomedica Scientifica
Background. Radiobiological research on chemical radioprotectors is relevant in the study of radiation injuries and in practical medicine during radiation therapy of cancer patients.
N. N. Omelchuk, Yu. G. Simakov, L. V. Volkova, V. I. Popadyuk, O. V. Anisimova, T. N. Khilko, O. E. Chernova   +6 more
doaj   +2 more sources

The Role of Radioprotector Agents in the Protection of Normal tissue [PDF]

Journal of Research in Applied and Basic Medical Sciences, 2021
The role of radioprotectors to reduce the cellular damage induced by ionizing radiation has been studied in human, animal and in vitro culture models. Radiation therapy cannot eradicate tumors successfully because of soft tissue damage.
Soraya Emamgholizadeh Minaei, Farideh Hoseini   +1 more
doaj   +1 more source

Radiotherapy-Induced Side Effects: Epidemiology, Pathogenesis, Prevention and Treatments. [PDF]

MedComm (2020)
Radiotherapy for malignancies frequently injures the organs’ systems through oxidative stress, fibrosis, inflammation, and vascular damage. This review systematically maps the epidemiology, pathogenesis, and emerging therapies to propose a mechanism‑network‑targeted framework for integrated, personalized care in radiation oncology.
Ma X, Zhang X, Zhao P, Yang J, Li Z, Han X, Wang Y, Cui Z, Liu N, Li M.   +9 more
europepmc   +2 more sources

Organoids in Precision Radiotherapy: Methodological Foundations, Tumor-Specific Evidence, and Translational Roadmaps. [PDF]

Cancer Med
ABSTRACT Background Radiotherapy remains a cornerstone of cancer treatment, while its efficacy is often limited by tumor radioresistance and the risk of normal tissue toxicity. Conventional preclinical models, including two‐dimensional (2D) cell cultures and murine xenografts, exhibit significant limitations in recapitulating human tumor ...
Zhu Y, Jiao Y, Xue J, Lv X, Qin S.
europepmc   +2 more sources

Radiation emergency medical countermeasures: Current formulary, identified gaps, and future approaches. [PDF]

Animal Model Exp Med
Current radiation medical countermeasures primarily focus on hematopoietic acute radiation syndrome (H‐ARS) using agents like granulocyte colony‐stimulating factor (G‐CSF), granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), and romiplostim, alongside treatments for internal contamination (Prussian blue, diethylenetriamine pentaacetate [DTPA ...
Ma WB, Yin RH, Ren GM, Zhang Y, Li LJ, Liu W, Chen T, Zhou W, Zu M, Yin RL, Shi XD, Wang L, Yang XM.   +12 more
europepmc   +2 more sources

Radioprotectors in Radiotherapy [PDF]

Journal of Radiation Research, 2001
Radiation Biology Division, Bhabha Atomic Research Centre, Mumbai 400 085, Department of Radiotherapy, All India Institute of Medical Sciences, New Delhi 110 029, India and Department of Radiation Biology and Medical Genetics, Graduate School of Medicine, Osaka University, B4, 2–2 Yamada-oka, Suita, Osaka 565–0871, Japan (Received, May 25, 2000 ...
C K, Nair, D K, Parida, T, Nomura
openaire   +2 more sources

Natural Guardians: Natural Compounds as Radioprotectors in Cancer Therapy. [PDF]

Int J Mol Sci
Cancer remains a significant global health challenge, with millions of deaths attributed to it annually. Radiotherapy, a cornerstone in cancer treatment, aims to destroy cancer cells while minimizing harm to healthy tissues.
Stasiłowicz-Krzemień A, Gościniak A, Formanowicz D, Cielecka-Piontek J.   +3 more
europepmc   +2 more sources

Natural radioprotectors on current and future perspectives: A mini-review

Journal of Pharmacy and Bioallied Sciences, 2022
Radiation therapy is used as the primary treatment for cancer. Eighty percent of cancer patients require radiation therapy during treatment or for medical purposes. During treatment, radiation causes various biological defects in the cells.
Pooja Shivappa, Grisilda Vidya Bernhardt
doaj   +1 more source

Genoprotective Effect of Some Flavonoids against Genotoxic Damage Induced by X-rays In Vivo: Relationship between Structure and Activity

Antioxidants, 2021
Flavonoids constitute a group of polyphenolic compounds characterized by a common gamma-benzo- pyrone structure considered in numerous biological systems to possess antioxidant capacity.
Miguel Alcaraz, Amparo Olivares, Daniel Gyingiri Achel, José Antonio García-Gamuz, Julián Castillo, Miguel Alcaraz-Saura   +5 more
doaj   +1 more source