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Salivary gland tissue chip screening identifies candidate radioprotective drugs [PDF]
Communications MedicineBackground Most head and neck cancer patients treated with ionizing radiation loose salivary gland function. Patients with decreased saliva have trouble eating, speaking and are predisposed to oral infections and tooth decay.
Lindsay R. Piraino +6 more
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THE PRINCESS PROJECT: FROM DIFFERENTIAL TO INTEGRAL EXPERIMENTS [PDF]
EPJ Web of Conferences, 2021 Following the shutdown of the CEA Valduc experimental facilities, where, for more than 50 years, IRSN used to perform experiments related to criticality safety, IRSN initiated a new project named PRINCESS (PRoject for IRSN Neutron physics and Criticality
Duhamel Isabelle +7 more
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Blood Science, 2021 . Radioprotection was previously considered as a function of hematopoietic stem cells (HSCs). However, recent studies have reported its activity in hematopoietic progenitor cells (HPCs).
Shanshan Zhang +10 more
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Determination of uranium and thorium in water for human consumption in the county of Angra dos Reis
Brazilian Journal of Radiation Sciences, 2021 Studies indicate that the presence of uranium and thorium radionuclides in the environment are of great importance in monitoring radiation levels. Humans can have a direct or indirect exposure.
Mariana Ferreira Gonçalves +2 more
doaj +1 more source
Aerosol and Air Quality Research, 2021 To evaluate the neurotoxic effects from exposure to airborne tungsten, we developed a method of generating mass concentrations of this element between 5 and 10 mg m−3, the time-weighted average occupational exposure limits. We then conducted measurements
Léo Macé +5 more
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Communications Biology, 2023 Local overexposure to ionizing radiation leads to chronic inflammation, vascular damage and cachexia. Here we investigate the kinetics of inflammatory cells from day (D)1 to D180 after mouse hindlimb irradiation and analyze the role of monocyte (Mo ...
Céline Loinard +5 more
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Renal toxicity and biokinetics models after repeated uranium instillation
Scientific Reports, 2023 During nuclear fuel processing, workers can potentially be exposed to repeated inhalations of uranium compounds. Uranium nephrotoxicity is well documented after acute uranium intake, but it is controversial after long-term or protracted exposure.
Laurie De Castro +12 more
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iScience, 2023 Summary: A better understanding of the molecular mechanism involving the lncRNA-miRNA-mRNA network underlying radiation damage can be beneficial for radioprotection.
Yong-jian Hu +12 more
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PERIOD 2 regulates low-dose radioprotection via PER2/pGSK3β/β-catenin/Per2 loop
iScience, 2022 Summary: During evolution, humans are acclimatized to the stresses of natural radiation and circadian rhythmicity. Radiosensitivity of mammalian cells varies in the circadian period and adaptive radioprotection can be induced by pre-exposure to low-level
Aris T. Alexandrou +17 more
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Large scale Vertical SEALing (VSEAL) test: Impact of gas migration on bentonite based vertical seals [PDF]
E3S Web of Conferences, 2023 The Institute for Radiological protection and Nuclear Safety (IRSN) has launched the VSEAL project to investigate the impact of gas migration on the long-term performance of bentonite based vertical sealing systems.
Mokni Nadia +2 more
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