Results 1 to 10 of about 51 (45)
Radioprotection and Radiomitigation: From the Bench to Clinical Practice
Biomedicines, 2020 The development of protective agents against harmful radiations has been a subject of investigation for decades. However, effective (ideal) radioprotectors and radiomitigators remain an unsolved problem. Because ionizing radiation-induced cellular damage
Rosario Salvador Palmer +2 more
exaly +3 more sources
Nuclear and Radiological Emergencies: Biological Effects, Countermeasures and Biodosimetry
Antioxidants, 2022 Atomic and radiological crises can be caused by accidents, military activities, terrorist assaults involving atomic installations, the explosion of nuclear devices, or the utilization of concealed radiation exposure devices.
Eduardo Gallego +2 more
exaly +3 more sources
Combining Pharmacological Countermeasures to Attenuate the Acute Radiation Syndrome—A Concise Review
Molecules, 2017 The goal of combined pharmacological approaches in the treatment of the acute radiation syndrome (ARS) is to obtain an effective therapy producing a minimum of undesirable side effects.
Martin Falk +2 more
exaly +3 more sources
Radiomitigators: Breakthroughs in Post-Radiation Recovery
AntioxidantsIonizing radiation (IR) exposure poses a significant biomedical challenge in clinical, occupational, and emergency contexts, highlighting the urgent need for effective medical countermeasures against acute radiation syndrome (ARS) and delayed effects of ...
José M Estrela +2 more
exaly +3 more sources
Antioxidants, 2018 Radiation countermeasures fall under three categories, radiation protectors, radiation mitigators, and radiation therapeutics. Radiation protectors are agents that are administered before radiation exposure to protect from radiation-induced injuries by ...
Nükhet Aykin-Burns +2 more
exaly +3 more sources
Redox BiologyThreats of irradiation (IR) exposure increase the need for radiomitigators. An important contributor to radiation injury is ferroptosis, triggered by the disbalanced redox metabolism.
Renee Fisher, Mert Akdogan
exaly +3 more sources
Development of radiation countermeasure agents for acute radiation syndromes
Animal Models and Experimental Medicine, Volume 6, Issue 4, Page 329-336, August 2023., 2023 Developments of radiation countermeasure agents for the acute radiation syndromes. Exposure to ionizing radiation induced direct or indirect damage effects on molecules, cells, tissues and organs of the body. A number of radiation countermeasure agents that are currently under different status of development and target the core mechanisms of radiation ...
Bowen Guan, Deguan Li, Aimin Meng
wiley +1 more source
Cell Biology International, Volume 46, Issue 12, Page 2158-2172, December 2022., 2022 Abstract Reprimo (RPRM), a target gene of p53, is a known tumor suppressor. DNA damage induces RPRM, which triggers p53‐dependent G2 arrest by inhibiting cyclin B1/Cdc2 complex activation and promotes DNA damage‐induced apoptosis. RPRM negatively regulates ataxia‐telangiectasia mutated by promoting its nuclear‐cytoplasmic translocation and degradation,
Zixuan Li +10 more
wiley +1 more source
Journal of Advanced Research, 2023 Introduction: Effective agents that could confer long-term protection against ionizing radiation in vivo would have applications in medicine, biotechnology, and in air and space travel.
Elena Obrador +8 more
doaj +1 more source
Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022 The deleterious effects of ionizing radiation on the central nervous system (CNS) are poorly understood. Radiation exposure during an accidental nuclear explosion, nuclear war, or radiotherapy causes severe brain damage. As a result, the current work is carried out to assess the radioprotective potential of N‐acetyl‐L‐tryptophan (L‐NAT) in neuronal ...
Ravi Kumar +5 more
wiley +1 more source