Analysis of the Proteomic Profile in Serum of Irradiated Nonhuman Primates Treated with Ex-Rad, a Radiation Medical Countermeasure [PDF]
J Proteome Res, 2023 There are currently four radiation medical countermeasures that have been approved by the United States Food and Drug Administration to mitigate hematopoietic acute radiation syndrome, all of which are repurposed radiomitigators.
Manoj Maniar (14852406) +15 more
core +2 more sources
Avasopasem manganese acts as both a radioprotector and a radiomitigator of radiation-induced acute or late effects [PDF]
Frontiers in OncologyIntroduction The pentaazamacrocyclic superoxide dismutase mimetic, Avasopasem Manganese (AVA), has been shown in clinical trials to reduce the severity and duration of acute oral mucositis (OM) and acute esophagitis in patients treated for head and neck and lung cancers, respectively, by radiotherapy using ...
Brock J. Sishc +10 more
openaire +3 more sources
Frontiers in Pharmacology, 2021 The increasing risks of radiological or nuclear attacks or associated accidents have served to renew interest in developing radiation medical countermeasures.
Vijay K. Singh +2 more
doaj +2 more sources
Scientific Reports, 2021 To date, the United States Food and Drug Administration (FDA) has approved four drugs to mitigate hematopoietic acute radiation syndrome and all four are repurposed radiomitigators.
Yaoxiang Li +7 more
doaj +2 more sources
Current status of radiation countermeasures for acute radiation syndrome under advanced development
Journal of Radiation and Cancer Research, 2018 The availability of safe and effective radiation countermeasures for the military and civilian population represents a significant unmet medical need. To expedite the development of countermeasures for life-threating situations, the United States Food ...
Vijay K Singh +6 more
doaj +2 more sources
Echocardiography Differentiates Lethally Irradiated Whole-Body From Partial-Body Exposed Rats [PDF]
Frontiers in Cardiovascular Medicine, 2018 Background: Acute radiation syndrome (ARS) affects morbidity and mortality dependent on the amount of body exposed. We propose the use of echocardiography (EC) to differentiate between survivors and non-survivors by measuring changes in cardiac function (
Taeko Inoue +9 more
doaj +2 more sources
Radioprotective and Radiomitigative Effects of Melatonin in Tissues with Different Proliferative Activity [PDF]
Antioxidants, 2021 We used various markers to analyze damage to mouse tissues (spleen and cerebral cortex) which have different proliferative activity and sensitivity to ionizing radiation (IR). We also assessed the degree of modulation of damages that occurs when melatonin is administered to mice prior to and after their X-ray irradiation.
Serazhutdin A. Abdullaev +2 more
openaire +3 more sources
Delivery of a mitochondria‐targeted antioxidant from biocompatible, polymeric nanofibrous scaffolds
FEBS Open Bio, Volume 11, Issue 1, Page 35-47, January 2021., 2021 Using electrospinning, we fabricated a biocompatible nanofibrous scaffold with mitochondrial antioxidant JP4‐039. Electron paramagnetic resonance spectroscopy tracked an initial burst release of JP4‐039 within the first 20 min followed by a sustained release over 72 h.
Yasaman Hamedani +5 more
wiley +1 more source
Neuroprotective agents effective against radiation damage of central nervous system
Neural Regeneration Research, 2022 Ionizing radiation caused by medical treatments, nuclear events or even space flights can irreversibly damage structure and function of brain cells. That can result in serious brain damage, with memory and behavior disorders, or even fatal oncologic or ...
Mária Lalkovicova
doaj +1 more source
Radiomitigators: prospects of use. comparative analysis of isolated and combined applications of interleukin 1Β [PDF]
, 2021 This article is devoted to the problem of protecting the population from radioactive exposure. The article considers a promising and relatively new class of anti-radiation drugs - radiomitigators.
Pershina, A. A. +7 more
core