Evaluation of deep space exploration risks and mitigations against radiation and microgravity [PDF]
Frontiers in Nuclear Medicine, 2023 Ionizing radiation and microgravity are two considerable health risks encountered during deep space exploration. Both have deleterious effects on the human body.
William Dobney +11 more
doaj +3 more sources
Radiation-induced intestinal injury: from molecular mechanisms to clinical translation [PDF]
Oncology ReviewsRadiation-induced intestinal injury (RIII) poses a significant clinical challenge for patients undergoing pelvic or abdominal radiotherapy, characterized by dual features of acute symptoms (diarrhea, abdominal pain, rectal bleeding) and chronic ...
Wenjue Wu +6 more
doaj +3 more sources
Ginkgo biloba Extract: A Preliminary Study on Its Radiomitigative Potential Using the Conventional Dicentric Chromosome Assay [PDF]
Brazilian Journal of Radiation SciencesRadioprotectors and radiomitigators can be substances of natural or synthetic origin that, once administered to the human body, are capable of preventing, protecting against, or reducing damage caused by radiation.
Julio Cesar Gomes da Silva +5 more
doaj +3 more sources
Ionizing Radiation, Antioxidant Response and Oxidative Damage: Radiomodulators [PDF]
Antioxidants (Basel), 2023 Ionizing radiation (IR) exposure can be deleterious for living tissues and eventually lead to illness or even death. DNA breakdown and the overproduction of highly reactive free radicals, reactive oxygen species (ROS) and reactive nitrogen species (RNS ...
Obrador E, Montoro A.
core +2 more sources
Radiomitigation by Melatonin in C57BL/6 Mice: Possible Implications as Adjuvant in Radiotherapy and Chemotherapy [PDF]
In Vivo, 2022 Melatonin (N-acetyl-5-methoxytryptamine), a chief secretory molecule of the pineal gland, has multiple properties, and numerous clinical investigations regarding its actions are in progress. This study investigated the radiomitigative role of melatonin in C57BL/6 mice.Melatonin (100 mg/kg) was orally administered once daily starting at 1 h on day 1 and
Akanchha Mani, Tripathi +2 more
openaire +3 more sources
Ядерна фізика та енергетика, 2019 Herein we present the results of studying the effects of different isotopes of magnesium, magnetic 25Mg and nonmagnetic 24Mg, upon the post-radiation recovery of yeast cells, S.
L. V. Avdeeva +4 more
doaj +3 more sources
Gene Therapy for Systemic or Organ Specific Delivery of Manganese Superoxide Dismutase
Antioxidants, 2021 Manganese superoxide dismutase (MnSOD) is a dominant component of the antioxidant defense system in mammalian cells. Since ionizing irradiation induces profound oxidative stress, it was logical to test the effect of overexpression of MnSOD on ...
Joel S. Greenberger +2 more
doaj +2 more sources
466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator
Journal of Clinical and Translational Science, 2023 OBJECTIVES/GOALS: We have designed an analogue of the Vitamin E tocotrienols called tocoflexol, which improves their pharmacokinetic limitations to make it an effective radiation medical countermeasure.
Shivangi Shrimali +7 more
doaj +2 more sources
Space Radiation Protection Countermeasures in Microgravity and Planetary Exploration
Life, 2021 Background: Space radiation is one of the principal environmental factors limiting the human tolerance for space travel, and therefore a primary risk in need of mitigation strategies to enable crewed exploration of the solar system. Methods: We summarize
Carlos A. Montesinos +10 more
doaj +2 more sources
Gut metabolite Urolithin A mitigates ionizing radiation‐induced intestinal damage [PDF]
Journal of Cellular and Molecular Medicine, Volume 25, Issue 21, Page 10306-10312, November 2021., 2021 Abstract Ionizing radiation (IR)‐induced intestinal damage is the major and common injury of patients receiving radiotherapy. Urolithin A (UroA) is a metabolite of the intestinal flora of ellagitannin, a compound found in fruits and nuts such as pomegranates, strawberries and walnuts.
Yuanyang Zhang +7 more
wiley +2 more sources