Results 31 to 40 of about 333 (138)

Feasibility study evaluating arrhythmogenesis and cardiac damage after heart‐base irradiation in mice: A brief communication

Veterinary Medicine and Science, Volume 6, Issue 4, Page 1009-1016, November 2020., 2020
This article summarises the results of a feasibility study evaluating arrhythmogenesis and cardiac damage after heart‐base irradiation in mice. After delivery of a severely hypofractionated radiation protocol to the proximal heart of mice, no arrhythmogenesis was elicited and minimal histologic change was found.
James Elliott, Keith Linder, Michael W. Nolan   +2 more
wiley   +1 more source

An Analysis of the Serum Metabolomic Profile for the Radiomitigative Effect of the Thrombopoietin Receptor Agonist Romiplostim in Lethally Whole-Body-Irradiated Mice [PDF]

Metabolites, 2022
The thrombopoietin receptor agonist romiplostim (RP) was recently approved by the US Food and Drug Administration for improving survival in patients acutely exposed to myelosuppressive doses of radiation. Our previous studies with mice have shown that RP administration after lethal irradiation not only completely rescues irradiated mice but also shows ...
Yoshiaki Sato, Masaru Yamaguchi, Ikuo Kashiwakura   +2 more
openaire   +3 more sources

Tocotrienol‐Rich Fraction from Rice Bran Demonstrates Potent Radiation Protection Activity

Evidence-Based Complementary and Alternative Medicine, Volume 2015, Issue 1, 2015., 2015
The vitamin E analogs δ‐tocotrienol (DT3) and γ‐tocotrienol (GT3) have significant protective and mitigative capacity against the detrimental effects of ionizing radiation (IR). However, the expense of purification limits their potential use. This study examined the tocotrienol‐rich fraction of rice bran (TRFRB) isolated from rice bran deodorizer ...
Kimberly J. Krager, E. Nathalie Pineda, Sujay V. Kharade, Mary Kordsmeier, Luke Howard, Philip J. Breen, Cesar M. Compadre, Martin Hauer-Jensen, Nukhet Aykin-Burns, Kailash Manda   +9 more
wiley   +1 more source

A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death

, 2011
The risk of radionuclide release in terrorist acts or exposure of healthy tissue during radiotherapy demand potent radioprotectants/radiomitigators.
Klein-Seetharaman, Judith, Michael W. Epperly, Natalia A. Belikova, Irina I. Vlasova, Vlasova, Irina I., Stoyanovsky, Detcho A., Jeffrey Atkinson, Atkinson, Jeffrey, Huang, Zhentai, Fletcher, Jackie, Epperly, Michael W., Yulia Y. Tyurina, Weihong Feng, Kagan, Valerian E., Jiang, Jianfei, Yongsheng Wang, Yanamala, Naveena, Samhan-Arias, Alejandro K., Akihiro Maeda, Linda Pearce, Kapralov, Alexandr A., Wang, Hong, Tyurina, Yulia Y., Maeda, Akihiro, Detcho A. Stoyanovsky, Hülya Bayîr, Amoscato, Andrew A., Peterson, Jim, Jackie Fletcher, Belikova, Natalia A., Feng, Weihong, Hong Wang, Vladimir A. Tyurin, Jianfei Jiang, Wang, Yongsheng, Valerian E. Kagan, Bayîr, Hülya, Alexandr A. Kapralov, Naveena Yanamala, Pearce, Linda, Andrew A. Amoscato, Greenberger, Joel S., Pitt, Bruce R., Karla Wasserloos, Alejandro K. Samhan-Arias, Judith Klein-Seetharaman, Tyurin, Vladimir A., Jim Peterson, Zhentai Huang, Joel S. Greenberger, Wasserloos, Karla, Bruce R. Pitt   +51 more
core   +2 more sources

Vitamin E Analogs as Radiation Response Modifiers

Evidence-Based Complementary and Alternative Medicine, Volume 2015, Issue 1, 2015., 2015
The potentially life‐threatening effects of total body ionizing radiation exposure have been known for more than a century. Despite considerable advances in our understanding of the effects of radiation over the past six decades, efforts to identify effective radiation countermeasures for use in case of a radiological/nuclear emergency have been ...
Pankaj K. Singh, Sunil Krishnan, Madhu Bala   +2 more
wiley   +1 more source

Radioprotection and Radiomitigating Potential of Markhamia Tomentosa Extract Against Gamma Radiation-Induced Damage on Albino Wistar Rats

Iranian Journal of Medical Physics, 2023
Introduction: This study evaluated the efficacy of Markhamia tomentosa (MT) extract as a potential radiation countermeasure emphasising its radioprotective and radiomitigating properties.Material and Methods: Forty male albino Wistar rats aged 10-12 weeks were used for the study. Rats were divided into eight groups comprising five animals in each group.
Akinade, Taofeek, Akomolafe, Idowu
openaire   +2 more sources

Ghrelin Therapy Improves Survival after Whole‐Body Ionizing Irradiation or Combined with Burn or Wound: Amelioration of Leukocytopenia, Thrombocytopenia, Splenomegaly, and Bone Marrow Injury

Oxidative Medicine and Cellular Longevity, Volume 2014, Issue 1, 2014., 2014
Exposure to ionizing radiation alone (RI) or combined with traumatic tissue injury (CI) is a crucial life‐threatening factor in nuclear and radiological events. In our laboratory, mice exposed to 60Co‐γ‐photon radiation (9.5 Gy, 0.4 Gy/min, bilateral) followed by 15% total‐body‐surface‐area skin wounds (R‐W CI) or burns (R‐B CI) experienced an ...
Juliann G. Kiang, Min Zhai, Pei-Jyun Liao, Thomas B. Elliott, Nikolai V. Gorbunov, Jeannette Vasquez-Vivar   +5 more
wiley   +1 more source

Radiomodifying action, Pharmacokinetic and Biodistribution of Ethyl 3, 4, 5-trihydroxybenzoate-Implication in development of radiomitigator [PDF]

Scientific Reports, 2019
AbstractEthyl 3, 4, 5-trihydroxybenzoate (GAE) is a major bioactive constituent of Hippophae Rhamnoides L. leaves and extract prepared from H. rhamnoides leaves exhibited radioprotective and pharmacological activity. Radiomodifying properties of polyphenol compounds through free radical neutralizing have been reported earlier.
Pandey, Pranav K, Ahmed, B., Prasad, J., Bala, M., Khan, H. A.   +4 more
openaire   +2 more sources

Pegylated G‐CSF Inhibits Blood Cell Depletion, Increases Platelets, Blocks Splenomegaly, and Improves Survival after Whole‐Body Ionizing Irradiation but Not after Irradiation Combined with Burn

Oxidative Medicine and Cellular Longevity, Volume 2014, Issue 1, 2014., 2014
Exposure to ionizing radiation alone (radiation injury, RI) or combined with traumatic tissue injury (radiation combined injury, CI) is a crucial life‐threatening factor in nuclear and radiological accidents. As demonstrated in animal models, CI results in greater mortality than RI.
Juliann G. Kiang, Min Zhai, Pei-Jyun Liao, David L. Bolduc, Thomas B. Elliott, Nikolai V. Gorbunov, Pranela Rameshwar   +6 more
wiley   +1 more source

Mechanisms of Radiomitigative Cell Signaling Via Lysophosphatidic Acid Receptors

The FASEB Journal, 2012
Radiomitigators attenuate radiation injury when administered after irradiation. Lysophosphatidic acid (LPA) a lipid mediator rescues apoptotically condemned cells. LPA protects IEC‐6 intestinal epithelial cells in vitro and intestinal crypts in vivo ...
Gabor Tigyi, Gyongyi Nagyne-Kiss, James Fells, Dianna Liu, Junming Yue, E Shuyu, Karin Thompson, Ryan Yates, Louisa Balazs, Abby Parrill, Wenlin Deng, Renuka Gupte, Duane Miller, Fang-Tsyr Lin   +13 more
openaire   +1 more source