Results 11 to 20 of about 29,053 (244)
Peptide receptor radionuclide therapy [PDF]
Best Practice & Research Clinical Gastroenterology, 2007 Abstract: On their plasma membranes, cells express receptor proteins with high affinity for regulatory peptides, such as somatostatin. Changes in the density of these receptors during disease, for example, overexpression in many tumors, provide the basis for new imaging methods.
Flavio Forrer +4 more
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Radionuclide therapy of hepatocellular carcinoma
Biomedical Imaging and Intervention Journal, 2006 Hepatocellular carcinoma (HCC) is a malignant tumour of the hepatocyte. It is a common malignancy worldwide and causes almost half a million deaths annually. Asia is a high risk area. Although surgery (hepatectomy or liver transplantation) is the main form of curative treatment, the majority of patients are not eligible for surgery due to extent of ...
FX Sundram
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Targeted Radionuclide Therapy [PDF]
Cancers, 2011 Targeted radiotherapy is an evolving and promising modality of cancer treatment. The killing of cancer cells is achieved with the use of biological vectors and appropriate radionuclides. Among the many advantages of this approach are its selectiveness in delivering the radiation to the target, relatively less severe and infrequent side effects, and the
Indukala Doddamane +2 more
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Targeted radionuclide therapy [PDF]
Medical Physics, 2008 Targeted radionuclide therapy (TRT) seeks molecular and functional targets within patient tumor sites. A number of agents have been constructed and labeled with beta, alpha, and Auger emitters. Radionuclide carriers spanning a broad range of sizes; e.g., antibodies, liposomes, and constructs such as nanoparticles have been used in these studies. Uptake,
Gerald L. DeNardo +2 more
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Theragnostic Radionuclide Pairs for Prostate Cancer Management: 64Cu/67Cu, Can Be a Budding Hot Duo
Biomedicines, 2022 Prostate cancer (PCa) is one of the preeminent causes of mortality in men worldwide. Theragnostic, a combination of therapy and diagnostic, using radionuclide pairs to diagnose and treat disease, has been shown to be a promising approach for combating ...
Anupriya Chhabra, Mathew L. Thakur
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World Journal of Nuclear Medicine, 2020 Prostate-specific membrane antigen (PSMA) is a Type II transmembrane glycoprotein which is extremely overexpressed in prostate cancer epithelial cells. Recently, PSMA-targeted small molecule labeled with 68Ga and 99mTc allowed precise molecular imaging ...
Esmail Jafari +3 more
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Management of biological waste of patients after radionuclide therapy
Радиационная гигиена, 2022 Radioactive waste management is a modern-day issue in terms of radiation safety due to the development of radionuclide therapy, the emergence of new radiopharmaceuticals, radionuclides, and treatment methods, which allow for radionuclide therapy in a day
L. A. Chipiga +7 more
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Radionuclides for Targeted Therapy: Physical Properties
Molecules, 2022 A search in PubMed revealed that 72 radionuclides have been considered for molecular or functional targeted radionuclide therapy. As radionuclide therapies increase in number and variations, it is important to understand the role of the radionuclide and ...
Caroline Stokke +2 more
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Nephrotoxicity after radionuclide therapies
Translational Oncology, 2022 Radioligand therapies have opened new treatment avenues for cancer patients. They offer precise tumor targeting with a favorable efficacy-to-toxicity profile. Specifically, the kidneys, once regarded as the critical organ for radiation toxicity, also show excellent tolerance to radiation doses as high as 50-60 Gy in selected cases.
Vikas Prasad +2 more
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Peptide Receptor Radionuclide Therapy
The Journal of Clinical Endocrinology & Metabolism, 2022 Abstract The concept of using a targeting molecule labeled with a diagnostic radionuclide for using positron emission tomography or single photon emission computed tomography imaging with the potential to demonstrate that tumoricidal radiation can be delivered to tumoral sites by administration of the same or a similar targeting molecule
Johannes Hofland +4 more
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