Results 51 to 60 of about 29,053 (244)

Possible Impurities in Radiopharmaceuticals and Corresponding Test Methods

Регуляторные исследования и экспертиза лекарственных средств, 2022
The main quality attributes of radiopharmaceuticals that ensure their effectiveness and safety and are unique to their specifications are activity, radionuclide identity, radionuclide purity, and radiochemical purity. The aim of this study was to analyse
G. E. Kodina, A. O. Malysheva, A. A. Larenkov, A. B. Bruskin   +3 more
doaj   +1 more source

Development of a DNA Aptamer‐Based Approach to Noninvasively Image CAR‐T Cells In Vivo and Traceless Enrichment In Vitro

Advanced Science, EarlyView.
A DNA aptamer (A3) with nanomolar affinity for CAR‐T cells is developed via Cell‐SELEX. In Nalm6 tumor‐bearing mice, Cy5‐labeled A3 enables long‐term fluorescence imaging and tracks the biodistribution of CAR‐T cells, with tumor signal peaking on day 14 after CAR‐T cell administration.
Minghui Chen, Pengzhao Chang, Zhen Zhang, Dan Liu, Rui Hou, Ming Shi, Jingjing Li, Kai Xu, Junnian Zheng   +8 more
wiley   +1 more source

RADIONUCLIDE IMAGING AND THERAPY OF NEUROENDOCRINE TUMOURS

Journal of Cancer and Allied Specialties, 2015
The incidence and prevalence of neuroendocrine tumours (NETs) are on the rise. Although NETs are a heterogeneous group of tumours, they have some similar properties, for example, that they can concentrate neuroamines and tend to have a high degree of ...
Shaunak Navalkissoor, Gopinath Gnanasegaran   +1 more
doaj   +1 more source

Recent Innovations and Nano-Delivery of Actinium-225: A Narrative Review

Pharmaceutics, 2023
The actinium-225 (225Ac) radioisotope exhibits highly attractive nuclear properties for application in radionuclide therapy. However, the 225Ac radionuclide presents multiple daughter nuclides in its decay chain, which can escape the targeted site ...
Sipho Mdanda, Lindokuhle M. Ngema, Amanda Mdlophane, Mike M. Sathekge, Jan Rijn Zeevaart   +4 more
doaj   +1 more source

In Vivo Radionuclide Generators for Diagnostics and Therapy [PDF]

Bioinorganic Chemistry and Applications, 2016
In vivo radionuclide generators make complex combinations of physical and chemical properties available for medical diagnostics and therapy. Perhaps the best-known in vivo generator is212Pb/212Bi, which takes advantage of the extended half-life of212Pb to execute a targeted delivery of the therapeutic short-livedα-emitter212Bi.
Patricia E. Edem, Jesper Fonslet, Andreas Kjær, Matthias Herth, Gregory Severin   +4 more
openaire   +6 more sources

Multi‐Module Micro/Nanorobots for Biomedical and Environmental Remediation Applications

Advanced Intelligent Systems, EarlyView.
Multi‐module microrobots (MNRs) have overcome the limitations of single‐module systems by integrating components such as propeller, actuator, manipulator, and imaging modalities. They show promise in biomedical applications, such as targeted drug delivery and tissue repair, as well as in environmental remediation, including pollutant removal.
Bairong Zhu, Amar Salehi, Lei Xu, Wei Yuan, Tingting Yu   +4 more
wiley   +1 more source

Potential Application of a Water‐Soluble Fullerene C60 Decorated with Diethylene Glycol in Treatment of Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
A new ethoxyethanol derivative of iminofullerene, F2, is synthesized and labeled with 99mTc to produce 99mTc‐F2. In vitro, compound F2 inhibits the activation of primary mouse bone marrow‐derived macrophages stimulated with lipopolysaccharide. Moreover, 99mTc‐F2 is selectively enriched in the injured joints of mice. Inflammatory macrophages play a role
Rui He, Alyssa Costello, Yanjie Liu, Weicheng Wang, Zhichang Zhang, Quanjun Cui, Xinlin Yang   +6 more
wiley   +1 more source

Monte Carlo modeling of the Yttrium-90 nanospheres application in the liver radionuclide therapy and organs doses calculation [PDF]

Nuclear Technology and Radiation Protection, 2016
Using the nano-scaled radionuclides in the radionuclide therapy significantly reduces the particles trapping in the organs vessels and avoids thrombosis formations. Additionally, uniform distribution in the target organ may be another benefit of
Ghavami Seyed Mostafa, Ghiasi Hosein, Mesbahi Asghar   +2 more
doaj   +1 more source

Introduction to Radiobiology of Targeted Radionuclide Therapy [PDF]

Frontiers in Medicine, 2015
During the last decades, new radionuclide-based targeted therapies have emerged as efficient tools for cancer treatment. Targeted radionuclide therapies (TRTs) are based on a multidisciplinary approach that involves the cooperation of specialists in several research fields.
Jean-Pierre ePOUGET, Catherine eLozza, Emmanuel eDeshayes, Emmanuel eDeshayes, Vincent eBoudousq, Isabelle eNAVARRO-TEULON, Isabelle eNAVARRO-TEULON   +6 more
openaire   +4 more sources

Review of the anatomical basis for predicting plutonium alpha particle radiation induced osteogenic cancers

The Anatomical Record, EarlyView.
Abstract Plutonium was discovered and first synthesized in the early 1940's. Several isotopes of plutonium are used in nuclear technologies, 238Pu for heat generation and 239Pu for energy production and weapons. Both isotopes emit alpha particles, which pose a significant radiation hazard when incorporated into the body.
Scott C. Miller
wiley   +1 more source