Results 61 to 70 of about 29,491 (205)
Journal of the Chinese Chemical Society, EarlyView.This Account showcases a modular, multi‐arm linker platform that decouples payload loading from antibody conjugation. By leveraging a computationally designed ACPGHA zinc‐binding motif, we demonstrate the construction of homogeneous antibody‐drug conjugates and theranostic antibody‐radionuclide conjugates with high payload loading. The multi‐arm linker
Cédric Grauffel +2 more
wiley +1 more source
Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 106-118, March 2025.This review article reports that quantification of hypoxic volumes using PET in the pre‐radiation therapy setting is of prognostic value and indicative of treatment response in non‐small cell lung cancer. Abstract Introduction Non‐small cell lung cancer (NSCLC) is the leading cause of cancer‐related death. Definitive treatment includes chemotherapy and
Carol Marks, Michelle Leech
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Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 25-33, March 2025.Occupational burnout is associated with negative feelings about the workplace and is often caused by a high workload and a non‐supportive workplace. It is associated with absenteeism, high turnover of staff and decreased patient care. More than half of the New Zealand participants and three quarters of the Australian participants had moderate levels of
Melissa Shields +2 more
wiley +1 more source
Molecular theranostics: principles, challenges and controversies
Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 156-164, March 2025.Molecular theranostics offers a powerful tool to drive precision medicine in nuclear oncology. While theranostics is not a new principle in nuclear medicine, recent advances in instrumentation and radiopharmacy have driven a reinvigoration and a broader suite of applications.
Geoffrey Currie
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Approach to radionuclide therapy dosimetry planning
Nuclear Energy and Technology, 2016 Control of radiation dose absorbed in pathological volume represents one of the challenging issues in the implementation of radionuclide therapy (RNT). This paper presents new approach based on estimation of radiopharmaceutical (RP) accumulated activity ...
Yu.V. Lysak +4 more
doaj +1 more source
Radionuclide-labelled nanoparticles for cancer combination therapy: a review
Journal of NanobiotechnologyRadionuclide therapy (RT) is widely used to advanced local cancers. However, its therapeutic efficacy is limited to the radiation resistance of cancer cells.
Na Sun, Tao Wang, Song Zhang
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Prostate Cancer Theranostics – Current Evidence and Future Considerations: a Brief Overview
Acta Clinica CroaticaDespite initial response to androgen inhibition, metastatic prostate cancer is invariably an incurable disease. New agents with different mechanisms of action are needed that are capable of producing clinical benefit and prolonging survival.
Antonela Njavro +7 more
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Radionuclide Therapy of Hepatocellular Carcinoma
Annals of the Academy of Medicine, Singapore, 2003 Introduction: Hepatocellular carcinoma (HCC) is a common malignancy worldwide. Surgical resection is generally accepted as the first choice treatment of HCC. Many non-surgical techniques have been developed and used for the treatment of inoperable HCC, with limited efficacy.
G H, Keng, F X, Sundram
openaire +2 more sources
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 460-473, March 2025.Abstract In oncology drug development, measuring drug concentrations at the tumor site and at the targeted receptor remains an ongoing challenge. Positron emission tomography (PET)‐imaging is a promising noninvasive method to quantify intratumor exposure of a radiolabeled drug (biodistribution data) and target saturation by treatment doses in vivo ...
Robin Michelet +8 more
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