Results 51 to 60 of about 54,960 (249)

Optimization of radiation protection in radionuclide therapy: Proposals for developing quality assurance programs

Радиационная гигиена
In order to ensure a high-quality and safe therapeutic process in radionuclide therapy, it is not sufficient to rely solely on safety monitoring within the framework of production control. Measures must be implemented within a quality assurance system as
A. V. Likhacheva, A. V. Vodovatov, L. A. Chipiga   +2 more
doaj   +1 more source

USE OF ¹⁷⁷Lu-PSMA FOR RADIONUCLIDE THERAPY IN PATIENTS WITH CASTRATE-RESISTANT PROSTATE CANCER

Сибирский онкологический журнал, 2021
Purpose of the study: to present current data regarding challenges in treatment of castration-resistant prostate cancer (CRPC) and the relationship between CRPC and the expression of prostate-specific membrane antigen (psma).Material and Methods.
A. A. Medvedeva, V. I. Chernov, E. A. Usynin, R. V. Zelchan, O. D. Bragina, N. A. Lushnikova   +5 more
doaj   +1 more source

Prostate lymphoscintigraphy and radio-guided surgery for sentinel lymph node identification in prostate cancer - Technique and results of the first 350 cases [PDF]

, 2003
Introduction: Having in mind the promising results of lymphoscintigraphy and intraoperative gamma probe application for the detection of sentinel lymph nodes (SLN) in malignant melanoma, breast and penis cancer, we tried to identify the SLN in prostate ...
Graf, Gerhard, Hamm, Michael, Harzmann, Rolf, Heidenreich, Peter, Keil, Mathias, Vogt, Harry, Wawroschek, Friedhelm, Weckermann, Dorothea, Wengenmair, Hermann   +8 more
core   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

The application of radionuclide therapy for breast cancer

Frontiers in Nuclear Medicine
Radionuclide-mediated diagnosis and therapy have emerged as effective and low-risk approaches to treating breast cancer. Compared to traditional anatomic imaging techniques, diagnostic radionuclide-based molecular imaging systems exhibit much greater ...
Anna Musket, Anna Musket, Sandra Davern, Brianna M. Elam, Brianna M. Elam, Philip R. Musich, Jonathan P. Moorman, Jonathan P. Moorman, Yong Jiang, Yong Jiang   +9 more
doaj   +1 more source

Direct estimation of activity concentration in regional voxels with application to 177Lu peptide receptor radionuclide therapy [PDF]

Med Phys
Abstract Background Quantitative SPECT in radionuclide‐therapy is limited by partial‐volume effects (PVEs). The implementation of regional voxels (r.v.), estimating mean activity concentrations in regions directly from projections, offers a promising alternative for the geometry‐specification to reduce PVEs.
Gustafsson J, Larsson E, Sjögreen Gleisner K.   +2 more
europepmc   +2 more sources

New developments in the experimental data for charged particle production of medical radioisotopes [PDF]

, 2015
The goal of the present work is to give a review of developments achieved experimentally in the field of nuclear data for medically important radioisotopes in the last three years.
Ditrói, F., Hermanne, A., Takács, S., Tárkányi, F.   +3 more
core   +2 more sources

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Assessment of poststress left ventricular ejection fraction by gated SPECT: comparison with equilibrium radionuclide angiocardiography [PDF]

, 2010
PURPOSE: We compared left ventricular (LV) ejection fraction obtained by gated SPECT with that obtained by equilibrium radionuclide angiocardiography in a large cohort of patients.
ACAMPA, WANDA, Capasso E, Caprio MG, CUOCOLO, ALBERTO, De Luca S, Liuzzi R, Luongo L, Nicolai E, PETRETTA, MARIO   +8 more
core  

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source