Results 141 to 150 of about 22,009 (263)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, Volume 13, Issue 35, 24 June 2026.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Radiolabeled Iron-Based Nanomaterials for Cancer Diagnosis and Therapy. [PDF]

Int J Nanomedicine
Ma YX, Dai KL, Sun N, Zhang S.
europepmc   +1 more source

A FAP‐Targeted SMDC Platform Enables Synergistic Radionuclide–Chemotherapy with PET‐Guided Evaluation

Advanced Science, Volume 13, Issue 36, 29 June 2026.
A fibroblast activation protein (FAP)‐targeted small molecule–drug conjugate (SMDC) platform is developed to integrate PET imaging with synergistic radionuclide–chemotherapy. Linker chemistry governs stability, exposure, and tolerability, with the VC linker providing superior in vivo performance.
Ruitao Yang, Hongxin Li, Zexin Xu, Baocheng Chen, Ningjie Li, Yuhua Zhong, Kongzhen Hu   +6 more
wiley   +1 more source

Immunohistochemical Evaluation of Integrin β6 Expression in Triple-Negative Breast Cancer as a Predictive Biomarker for Therapeutic and Diagnostic Radionuclides. [PDF]

Biomolecules
Tuffaha M, Hananeh W, Bangemann N, Tuffaha A, Starke M.   +4 more
europepmc   +1 more source

Multifunctional Eutectic Mixtures Enable Integrated Recovery of U, Pu, and Sr From Nuclear Waste

Advanced Science, Volume 13, Issue 36, 29 June 2026.
A novel class of multifunctional eutectic mixtures, crafted from crown ether and organophosphorus molecules, achieves highly efficient, simultaneous recovery of uranium, plutonium, and strontium from nuclear waste. The material operates via a dual “coordination‐encapsulation” mechanism within self‐assembled reverse‐micelle structures, offering a ...
Yifan Wang, Yanjun Lv, Qilong Tang, Huaixin Hao, Jianfeng Jia, Gang Ye, Jing Chen, Chao Xu, Zhipeng Wang   +8 more
wiley   +1 more source

Advancing towards cancer theragnostic by probing the ²²⁵Ac decay chain with ultra-high-resolution metallic magnetic calorimeter based detectors. [PDF]

Commun Med (Lond)
Maurer K, Unger D, Behe M, Knecht A, von Schoeler K, Hengstler D, Vitova T, Benešová-Schäfer M, Fleischmann A, Gastaldo L, Wängler C, Enss C, Schacherl B.   +12 more
europepmc   +1 more source

WSB.APP/PS1 mice develop age‐dependent cerebral amyloid angiopathy, cerebrovascular dysfunction, and white matter deficits

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Cerebrovascular deficits, including cerebral amyloid angiopathy (CAA), play a key role in Alzheimer's disease (AD) pathogenesis. Here, we characterize the susceptibility of the WSB/EiJ genetic context to human AD‐relevant cerebrovascular phenotypes. METHODS CAA and parenchymal plaque analysis and in vivo neurovascular imaging were
Olivia J. Marola, Asli Uyar, Kelly J. Keezer, Juan Antonio K. Chong Chie, Kevin J. Elk, Abigail E. Cullen, Kierra Eldridge, Scott Persohn, Jonathan Nyandu Kanyinda, Jennifer D. Whitesell, Julie A. Harris, Paul Salama, Ashley E. Walker, Gregory W. Carter, Michael Sasner, Paul R. Territo, Gareth R. Howell, Kristen D. Onos   +17 more
wiley   +1 more source

Cancer treatment by radioimmunotherapy: insights from a dynamical model of cancer stem cells and hypoxia effects. [PDF]

Sci Rep
Mvogo A, Essongo FE, Hubert Ben-Bolie G.
europepmc   +1 more source

A Robust Cost‐Effective Spectrophotometric Method for Nb Determination in Refractory Nb‐doped Gadolinium Zirconate: Overcoming Matrix Dissolution Challenges

Analytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT A simple, robust and cost‐effective analytical methodology was developed for the determination of niobium in highly refractory materials: Nb‐doped gadolinium zirconate (Gd2Zr2O7:Nb) and niobium pentoxide (Nb2O5). The challenge of digesting these matrices was successfully accomplished by establishing two independent dissolution procedures: (i ...
Poonam Verma, Annapurna Chandane
wiley   +1 more source

Functional Suitability Evaluation of Radioimmunoconjugates of Nanobodies against PD-L1 and HER2/neu for Tumor Theranostics. [PDF]

Sovrem Tekhnologii Med
Avrov KO, Shatik SV, Shashkova OA, Pinevich AA, Terekhina LA, Gryazeva IV, Zaitsev VV, Berlina MA, Stanzhevsky AA, Samoylovich MP.   +9 more
europepmc   +1 more source