Results 111 to 120 of about 54,698 (337)

The Impact of Emerging Bioconjugation Chemistries on Radiopharmaceuticals

Journal of Nuclear Medicine, 2019
The use of radiolabeled antibodies, immunoglobulin fragments, and other proteins are an increasingly important sector of research for diagnostic imaging and targeted radiotherapy in nuclear medicine.
Rachael Fay, J. Holland
semanticscholar   +1 more source

A Comprehensive Evaluation of Analytical Method Parameters Critical to the Reliable Assessment of Therapeutic mRNA Integrity by Capillary Gel Electrophoresis

ELECTROPHORESIS, EarlyView.
ABSTRACT In recent years, messenger ribonucleic acid (mRNA)‐lipid nanoparticle (LNP) biotherapeutics have demonstrated significant promise in disease treatment and prevention given their rapidly modifiable production processes and considerable capacity to adapt to complex or low‐yielding proteins of interest.
Jessica P. Tran, Jun Gao, Casey Lansdell, Barry Lorbetskie, Michael J. W. Johnston, Lisheng Wang, Xuguang Li, Huixin Lu   +7 more
wiley   +1 more source

Expanding a peptide-covalent probe hybrid for PET imaging of S. aureus driven focal infections

EJNMMI Radiopharmacy and Chemistry
Background The urgent demand for innovative theranostic strategies to combat bacterial resistance to antibiotics is evident, with substantial implications for global health. Rapid diagnosis of life-threatening infections can expedite treatment, improving
Jyotsna Bhatt Mitra, Saurav Chatterjee, Anuj Kumar, Elina Khatoon, Ashok Chandak, Sutapa Rakshit, Anupam Bandyopadhyay, Archana Mukherjee   +7 more
doaj   +1 more source

64Cu-based Radiopharmaceuticals in Molecular Imaging

Technology in Cancer Research and Treatment, 2019
Copper-64 (T1/2 = 12.7 hours; β+: 19%, β−: 38%) has a unique decay profile and can be used for positron emission tomography imaging and radionuclide therapy.
Yeye Zhou, Jihui Li, Xin Xu, Man Zhao, Bin Zhang, S. Deng, Yiwei Wu   +6 more
semanticscholar   +1 more source

Epigenomics‐guided precision oncology: Chromatin variants in prostate tumor evolution

International Journal of Cancer, EarlyView.
Abstract Prostate cancer is a common malignancy that in 5%–30% leads to treatment‐resistant and highly aggressive disease. Metastasis‐potential and treatment‐resistance is thought to rely on increased plasticity of the cancer cells—a mechanism whereby cancer cells alter their identity to adapt to changing environments or therapeutic pressures to create
Kira Furlano, Tina Keshavarzian, Nadine Biernath, Annika Fendler, Maria de Santis, Joachim Weischenfeldt, Mathieu Lupien   +6 more
wiley   +1 more source

Advanced Optical Microscopic Imaging Techniques for Imaging Amyloid Beta and Deciphering Alzheimer's Disease Pathogenesis

iRADIOLOGY, EarlyView.
Summary of optical microscopic imaging methods in Alzheimer's Diseases (AD) research. In addition to conventional microscopic imaging, some super‐resolution and deep‐imaging imaging techniques have been developed and utilized in AD studies. ABSTRACT Alzheimer's disease (AD) is a neurodegenerative disease characterized by a progressive decline in ...
Shiju Gu, Chongzhao Ran
wiley   +1 more source

Separation of Radiocopper 64/67Cu from the Matrix of Neutron-Irradiated Natural Zinc Applicable for 64Cu Production

Atom Indonesia, 2012
Radioisotope 64Cu is a promising radiometallic-isotope for molecular-targeted-radiopharmaceuticals. Having a half-life of 12.70 hours and emitting β+-radiation (E+ = 0.6531 MeV) as well as β—ray (E = 0.5787 MeV), it is widely used in the form of ...
S. Soenarjo, Sriyono, W.Y. Rahman, E. Sarmini, Hambali , Triyanto   +5 more
doaj  

Clinical summary of fibroblast activation protein inhibitor-based radiopharmaceuticals: cancer and beyond

European Journal of Nuclear Medicine and Molecular Imaging, 2022
Mengting Li, Muhsin H Younis, Yongxue Zhang, W. Cai, Xiaoli Lan   +4 more
semanticscholar   +1 more source

Adverse Events of Diagnostic Radiopharmaceuticals: A Systematic Review.

Seminars in nuclear medicine, 2019
Diagnostic radiopharmaceuticals used in nuclear medicine can cause adverse events. Information on these adverse events is available in case reports and databases but may not be readily accessible to healthcare professionals.
N. Schreuder, D. Koopman, P. L. Jager, J. Kosterink, E. V. van Puijenbroek   +4 more
semanticscholar   +1 more source

Impacts of Inorganic Arsenic Exposure on Genetic Stability of Human Mesenchymal Stromal Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Human mesenchymal stem/stromal cells (hMSCs) can differentiate into mesoderm‐type cells, making them suitable candidates for tissue repair therapies. However, their relatively low frequency in adult tissue necessitates ex vivo expansion prior to regenerative medicine applications, and therefore, long‐term hMSC genetic stability during ...
Marc A. Beal, Melanie Coughlan, Andrée Nunnikhoven, Reena Corbane, Cathy Cummings‐Lorbetskie, Andrea Rowan‐Carroll, Tanvi Sharma, Andrew Williams, Jessie R. Lavoie, Andrew Stalker, Asish Mohapatra, Matthew J. Meier   +11 more
wiley   +1 more source