Results 51 to 60 of about 34,871 (236)

Imaging with iodine-123-labelled radiopharmaceuticals [PDF]

, 2011
123I-labelled radiopharmaceuticals 206123I-meta-iodo-benzyl-guanidine (123I-MIBG) 208β‎-methyl-p-[123I]iodo-phenyl-pentadecanoic acid (123I-BMIPP) 210Nuclear cardiology techniques offer the potential to image aspects of myocardial physiology and ...
Nikant Sabharwal, Chee Yee Loong, Andrew Kelion   +2 more
core   +1 more source

An Overview of Emerging Trends in Targeted Therapy of Triple-Negative Breast Cancer

International Journal of Breast Cancer
Triple-negative breast cancer (TNBC) is a biologically diverse, highly aggressive class of breast cancer defined by the absence of estrogen, progesterone, and HER2 receptors.
Anuj Kumar, Suresh Subramanian
doaj   +1 more source

Optimal clinical protocols for total-body 18F-FDG PET/CT examination under different activity administration plans

EJNMMI Physics, 2023
Background Highly sensitive digital total-body PET/CT scanners (uEXPLORER) have great potential for clinical applications and fundamental research. Given their increasing sensitivity, low-dose scanning or snapshot imaging is now possible in clinics ...
Yanchao Huang, Meng Wang, Li Jiang, Lijuan Wang, Li Chen, Qiaoyu Wang, Jiatai Feng, Jingyi Wang, Wanbang Xu, Hubing Wu, Yanjiang Han   +10 more
doaj   +1 more source

Affinity‐Tuned Albumin Hitchhiking Extends the Bioorthogonal Capture Window in Pretargeting Radiotheranostics

Advanced Healthcare Materials, EarlyView.
Pharmacokinetic engineering of clickable radioligands was achieved via albumin hitchhiking approach within a pretargeted radiotheranostics delivery platform. This approach reduced rapid renal elimination, expanded bioorthogonal capture window, boosted tumor uptake by ∼3.5‐fold, and improved the tumor‐to‐liver ratio by ∼6‐fold.
Xie He, Nicholas L. Fletcher, Gayathri R. Ediriweera, Yifei Zhu, James Humphries, Christopher B. Howard, Jiazheng Wang, Craig A. Bell, Kristian Kempe, Kristofer J. Thurecht   +9 more
wiley   +1 more source

Application of chiral 2-isoxazoline for the synthesis of syn-1,3-diol analogs

Beilstein Journal of Organic Chemistry, 2019
The asymmetric cycloaddition of TIPS nitronate catalyzed by “Cu(II)-bisoxazoline” gave the 2-isoxazoline product in 95% yield, which was converted into tert-butyl (3S,5R)-6-hydroxy-3,5-O-isopropylidene-3,5-dihydroxyhexanoate in 14 steps through a β ...
Juanjuan Feng, Tianyu Li, Jiaxin Zhang, Peng Jiao   +3 more
doaj   +1 more source

The Development and Pilot Clinical Study of CD147 Targeted Antagonistic Peptide Probe for Tumor Imaging

Advanced Science, EarlyView.
This study establishes [68Ga]Ga‐DOTA‐AP9 as a first‐in‐human CD147‐targeted PET tracer with favorable safety and specific tumor uptake. Tracer accumulation correlates with CD147 expression in patients, enabling noninvasive quantification of CD147‐positive malignancies.
Xiaokun Ma, Rui Guo, Dongfeng Niu, Yufei Song, Zhenyao Zhang, Xiangxi Meng, Lili Mao, Haifeng Huang, Hua Zhu, Zhi Yang, Teli Liu   +10 more
wiley   +1 more source

Activatable theranostic prodrug scaffold with tunable drug release rate for sequential photodynamic and chemotherapy

Smart Molecules
Glutathione (GSH)‐activated prodrugs are promising for overcoming the limitations of conventional anti‐tumor drugs. However, current GSH‐responsive disulfide groups exhibit unregulated reactivity, making it impossible to precisely control the drug ...
Si‐Yu Wang, Ying‐Hao Pan, Yu‐Chen Qu, Xiao‐Xiao Chen, Na Shao, Li‐Ya Niu, Qing‐Zheng Yang   +6 more
doaj   +1 more source

Applications of carbon dots on tumour theranostics

View, 2021
Carbon dots (CDs) have been extensively investigated as prime candidates for developing tumour theranostic platform due to their tunable fluorescence emission and excitation, good photostability, high water solubility and biocompatibility.
Hao Wu, Wen Su, Huimin Xu, Yang Zhang, Yunchao Li, Xiaohong Li, Louzhen Fan   +6 more
doaj   +1 more source

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source

Preclinical evaluation of [18F]FP-CIT, the radiotracer targeting dopamine transporter for diagnosing Parkinson’s disease: pharmacokinetic and efficacy analysis

EJNMMI Research
Background N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane (FP-CIT), the representative cocaine derivative used in dopamine transporter imaging, is a promising biomarker, as it reflects the severity of Parkinson’s disease (PD).
Jae Hun Ahn, Min Hwan Kim, Kyongkyu Lee, Keumrok Oh, Hyunwoo Lim, Hee Seup Kil, Soon Jeong Kwon, Jae Yong Choi, Dae Yoon Chi, Yong Jin Lee   +9 more
doaj   +1 more source