Results 71 to 80 of about 34,696 (251)
Chemistry – A European Journal, EarlyView.Chemoenzymatic reactions using the siderophore synthetase DesD from Salinispora tropica and hydroxamic acid substrates (native, non‐native) with different multiplicities (monomer, dimer) and components (homo‐/heterodimer) followed different reaction trajectories, which biased the architectures of the chelator major products and indicated DesD contains ...
Callum A. Rosser +2 more
wiley +1 more source
Molecules, 2014 The epidermal growth factor receptor (EGFR) is overexpressed in many cancers, including breast, ovarian, endometrial and non-small cell lung cancer. An EGFR-specific imaging agent could facilitate clinical evaluation of primary tumors or metastases.
Mingxia Zhao +5 more
doaj +1 more source
Peptide Marriages: Modular Assembly of Multi‐Agonist Therapeutics
Chemistry – A European Journal, EarlyView.A modular polyethylene glycol (PEG) scaffold enables rapid assembly of dual peptide agonists using strain‐promoted azide–alkyne cycloaddition (SPAAC) and copper‐catalysed azide–alkyne cycloaddition (CuAAC). Glucagon‐like peptide‐1 (GLP‐1) and amylin agonists were combined with controlled valency, yielding low‐picomolar activity and receptor‐selective ...
Kristina A. Kostadinova +11 more
wiley +1 more source
Oligonucleotides as Radiopharmaceuticals
, 2006 Oligonucleotide radiopharmaceuticals is a slowly but steadily progressing field. With a panel of labeling and imaging techniques mastered by several groups, imaging of oligonucleotides is now relatively accessible and will be applied to more and more trials of oligonucleotide pharmacology.
openaire +2 more sources
Epilepsia, EarlyView.Abstract Understanding the mechanisms underlying post‐traumatic epilepsy (PTE) following traumatic brain injury (TBI), and developing strategies to prevent or modify its progression, has been the focus of large collaborative efforts within the epilepsy and TBI research communities for over a decade.
Elisa R. Zanier +82 more
wiley +1 more source
Radiopharmaceuticals and applications
, 2006 Os radiofármacos são compostos, sem ação farmacológica, que têm na sua composição um radionuclídeo e são utilizados em Medicina Nuclear para diagnóstico e terapia de várias doenças.
Ferreira, Domingos Carvalho +5 more
core +1 more source
Exploration, EarlyView.We developed a dissolvable microneedle patch that locally delivers a radiolabeled coordination polymer designed to simultaneously destroy tumor cells and stimulate antitumor immunity through STING activation and pyroptosis. This strategy significantly inhibited melanoma growth and improved the effectiveness of immune checkpoint therapy, highlighting a ...
Pian Yu +12 more
wiley +1 more source
Imaging with iodine-123-labelled radiopharmaceuticals
, 2011 123I-labelled radiopharmaceuticals 206123I-meta-iodo-benzyl-guanidine (123I-MIBG) 208β-methyl-p-[123I]iodo-phenyl-pentadecanoic acid (123I-BMIPP) 210Nuclear cardiology techniques offer the potential to image aspects of myocardial physiology and ...
Nikant Sabharwal +2 more
core +1 more source
PET/CT and PET/MRI in Cancer Diagnosis and Management: A Comparative Clinical Perspective
iMetaMed, EarlyView.This review compares PET/CT and PET/MRI in cancer imaging, highlighting their complementary roles for precise diagnosis and staging. It evaluates their technical strengths, clinical performance across various cancers, and future directions, including AI and novel tracers.
Zijian Ding +5 more
wiley +1 more source
SINTESIS DAN KARAKTERISASI NUKLEOTIDA BERTANDA [α-32P]ATP
Jurnal Riset Kimia, 2019 The utilization of nuclear technology in health sector with molecular techniques is increasingly developed today, especially in Indonesia. One of which is nucleotide compound marked with [α-32P]ATP, this compound has been used as tracer for ...
Wira Yusril Rahman +6 more
doaj +1 more source