Results 31 to 40 of about 34,871 (236)

Methodological Approaches to Preclinical Evaluation of General Toxicity of Therapeutic Radiopharmaceuticals

open access: yesРегуляторные исследования и экспертиза лекарственных средств, 2021
Radiopharmaceuticals differ from other medicines mainly by the specific nature of their pharmacological action based on radioactivity, by absence of multiple-dose regimens, and by miniscule concentrations of the active pharmaceutical ingredient (10-9–10 ...
O. E. Klementyeva   +2 more
doaj   +1 more source

Diagnostic and Therapeutic Radiopharmaceuticals: A “Hot” Topic [PDF]

open access: yes, 2023
Diagnostic and Therapeutic Radiopharmaceuticals: A “Hot ...
Craig W. Lindsley (1327038)   +2 more
core   +3 more sources

Radiopharmaceuticals Used in Molecular Imaging [PDF]

open access: yes, 2021
Molecular imaging technology can be used for many applications, including drug development, clinical investigations,and diagnostic techniques. Molecular imaging techniques depend upon molecular mechanisms operating in vivo.
Ekinci, Meliha   +2 more
core   +2 more sources

Research Progress of Metal-Based Radiopharmaceuticals Targeting Somatostatin Receptor

open access: yesHe huaxue yu fangshe huaxue, 2023
Neuroendocrine tumors(NETs) are a group of heterogeneous tumors originating from neuroendocrine cells. They can occur anywhere in the body, most commonly in the digestive tract, pancreas, and lungs.
QIN Xiang-yu, SHEN Lang-tao
doaj   +1 more source

Radiopharmaceutical Therapy [PDF]

open access: yesHealth Physics, 2019
Abstract Radiopharmaceutical therapy involves the use of radionuclides that are either conjugated to tumor-targeting agents (e.g., nanoscale constructs, antibodies, peptides, and small molecules) or that concentrate in tumors through natural physiological mechanisms that occur predominantly in neoplastic cells.
openaire   +2 more sources

Preparation of radiopharmaceuticals labeled with metal radionuclides [PDF]

open access: yes, 1992
We recently developed a useful zinc-62/copper-62 generator and are presently evaluating copper-62 radiopharmaceuticals for clinical studies. While developing these copper-62 radiopharmaceuticals, in collaboration with the University of Missouri Research ...
Welch, M. J.
core   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi   +19 more
wiley   +1 more source

Radiopharmaceuticals to in vivo characterize adrenal incidentalomas: the integrated role of radionuclide and radiological techniques. [PDF]

open access: yes, 2008
To illustrate the role of radiopharmaceuticals in characterizing non-hypersecreting adrenal masses, 56 patients with non-hypersecreting unilateral adrenal tumors detected on CT and/or MR underwent adrenal scintigraphy.
MAUREA, SIMONE, SALVATORE, MARCO
core   +3 more sources

Bivalent non-human gal-α1-3-gal glycan epitopes in the Fc region of a monoclonal antibody model can be recognized by anti-Gal-α1-3-Gal IgE antibodies

open access: yesmAbs, 2023
Monoclonal antibody (mAb) production using non-human cells can introduce non-human glycan epitopes including terminal galactosyl-α1–3-galactose (α1–3-Gal) moieties. Cetuximab is a commercial mAb associated with causing anaphylaxis in some patients due to
Grayson Hatfield   +5 more
doaj   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao   +7 more
wiley   +1 more source

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