Results 21 to 30 of about 34,696 (251)

Synthesis and Evaluation of Novel Norfloxacin Isonitrile ^99mTc Complexes as Potential Bacterial Infection Imaging Agents

Pharmaceutics, 2021
To develop potential technetium-99m single-photon emission computed tomography (SPECT) imaging agents for bacterial infection imaging, the novel norfloxacin isonitrile derivatives CN4NF and CN5NF were synthesized and radiolabeled with a [99mTc][Tc(I ...
Si’an Fang, Yuhao Jiang, Di Xiao, Xuran Zhang, Qianqian Gan, Qing Ruan, Junbo Zhang   +6 more
doaj   +1 more source

The Radiobiology of Radiopharmaceuticals

Seminars in Radiation Oncology, 2021
Radiopharmaceutical therapy or targeted radionuclide therapy (TRT) is a well-established class of cancer therapeutics that includes a growing number of FDA-approved drugs and a promising pipeline of experimental therapeutics. Radiobiology is fundamental to a mechanistic understanding of the therapeutic capacity of these agents and their potential ...
Zachary S, Morris, Andrew Z, Wang, Susan J, Knox   +2 more
openaire   +3 more sources

Clinical translation of theranostic radiopharmaceuticals: Current regulatory status and recent examples [PDF]

, 2019
With the development of ever more radiopharmaceuticals suitable for theranostic applications, translation of novel compounds from the preclinical stage towards clinical application becomes a bottleneck for the advances in Nuclear Medicine.
Rangger C., Mikolajczak R., Clemens Decristoforo, Hubalewska-Dydejczyk A., Decristoforo, Clemens, Maina T., Christine Rangger, Piotr Garnuszek, Garnuszek, Piotr, Erba, Paola, Decristoforo C., Kolenc Peitl, Petra, Hubalewska-Dydejczyk, Alicja, Petra Kolenc Peitl, Theodosia Maina, Mikołajczak, Renata, Maina, Theodosia, Renata Mikolajczak, Paola Erba, Rangger, Christine, Erba P., Garnuszek P., Kolenc Peitl P., Alicja Hubalewska‐Dydejczyk   +23 more
core   +1 more source

Innovative radiopharmaceuticals in oncology and neurology [PDF]

, 2017
The aim of this Research Topic was to assemble a series of articles describing basic, preclinical and clinical research studies on radiopharmaceuticals and nuclear medicine.
Michel Cherel, Jacques Barbet, Francoise Kraeber-Bodere, Barbet, Jacques, Kraeber-Bodéré, Françoise, Guilloteau, Denis, Chérel, Michel, Bodere, Francoise Kraeber, Denis Guilloteau   +8 more
core   +1 more source

Recent Applications of Ambient Ionization Mass Spectrometry for Environmental Pollutant Detection [PDF]

Zhipu Xuebao, 2023
Along with the industrial development and human society progress, large number of pollutants have been discharged to induce the environmental pollution, which have attracted global attentions.
QIN Jing-yi, OUYANG Jin, NA Na
doaj   +1 more source

Pharmacovigilance in radiopharmaceuticals

Indian Journal of Nuclear Medicine, 2016
Indian Pharmacopoeia Commission is Committed for maintaining the standards of drugs including Radiopharmaceuticals (RPs) by publishing Indian Pharmacopoeia. These RPs are being used in India for diagnostic or therapeutic purpose. RPs though contain relatively small quantities of active ingredient and administered in small volumes could cause some ...
Kumar, Rishi, Kalaiselvan, Vivekanandan, Kumar, Rakesh, Verma, Ravendra, Singh, Gyanendra Nath   +4 more
openaire   +3 more sources

Ginsenoside Rb1 can ameliorate the key inflammatory cytokines TNF-α and IL-6 in a cancer cachexia mouse model

BMC Complementary Medicine and Therapies, 2020
Background Cancer cachexia is a severe condition that leads to the death of advanced cancer patients, and approximately 50~80% of cancer patients have cancer cachexia.
Shuai Lu, Yubo Zhang, Huajun Li, Jing Zhang, Yingqian Ci, Mei Han   +5 more
doaj   +1 more source

Research Progress of Metal-Based Radiopharmaceuticals Targeting Somatostatin Receptor

He huaxue yu fangshe huaxue, 2023
Neuroendocrine tumors(NETs) are a group of heterogeneous tumors originating from neuroendocrine cells. They can occur anywhere in the body, most commonly in the digestive tract, pancreas, and lungs.
QIN Xiang-yu, SHEN Lang-tao
doaj   +1 more source

Nuclear medicine as a tool for diagnosis and targeted cancer therapy

Бюллетень сибирской медицины, 2018
The main trends and prospects of development of nuclear medicine, problems and possible ways of their solution are considered in the article. The main scientific directions in the development of radiopharmaceuticals for the diagnosis and radionuclide ...
V. I. Chernov, A. A. Medvedeva, I. G. Sinilkin, R. V. Zelchan, O. D. Bragina, E. L. Choynzonov   +5 more
doaj   +1 more source

Methodological Approaches to Preclinical Evaluation of General Toxicity of Therapeutic Radiopharmaceuticals

Регуляторные исследования и экспертиза лекарственных средств, 2021
Radiopharmaceuticals differ from other medicines mainly by the specific nature of their pharmacological action based on radioactivity, by absence of multiple-dose regimens, and by miniscule concentrations of the active pharmaceutical ingredient (10-9–10 ...
O. E. Klementyeva, A. S. Lunev, C. A. Lunyova   +2 more
doaj   +1 more source