Results 171 to 180 of about 14,471 (229)

Coupling oxidative de-stabilization with immune activation overcomes radioresistance in hepatocellular carcinoma. [PDF]

Mol Cancer
Liu J, Mi Z, Tan H, Duan J, Huang F, Guo S, Li Y, Wu J, Yang M, Liao Y, Ma X, Liang Q, Zhang W, Fan X, Rong P.   +14 more
europepmc   +1 more source

Interplay Between Epigenetics and Reactive Oxygen Species in Tumor Radioresistance: Mechanisms and Therapeutic Strategies for Radiotherapy. [PDF]

Cancer Med
Yang Z, Wang J, Wang G, Zhu J, Zhang S, Guo W.   +5 more
europepmc   +1 more source

Radiosensitization

, 2018
Weber, K. J., Witte, S., Rothkamm, K., Rave-Fraenk, Margret, Virsik-Koepp, Patricia, Kupper, J. H., Rudat, V., Lobrich, M.   +7 more
openaire   +1 more source

The Role of Thioredoxin Reductase in Gold Nanoparticle Radiosensitization Effects [PDF]

Nanomedicine, 2018
AIM: To identify new mechanisms responsible for the radiosensitization effect of gold nanoparticles (GNPs).MATERIALS & METHODS: A549 lung carcinoma cells were incubated with 10-nm GNPs during 6 or 24 h before to be exposed to 25 keV/μm protons or 225
Sébastien Penninckx, Anne-Catherine Heuskin, Carine Michiels   +2 more
exaly   +2 more sources

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Modifiers of radiosensitivity

Experientia, 1989
Many different methods exist by which the radiosensitivity of cells, and hence of normal tissues and tumours, can be manipulated. Several of these can be traced to a common redox pathway involving competition between oxidising and reducing species. Others involve the biochemical enzyme systems required for removal of DNA lesions.
A, Rojas, J, Denekamp
openaire   +2 more sources

Cancer Radiosensitizers

Trends in Pharmacological Sciences, 2018
Radiotherapy (RT) is a mainstay treatment for many types of cancer, although it is still a large challenge to enhance radiation damage to tumor tissue and reduce side effects to healthy tissue. Radiosensitizers are promising agents that enhance injury to tumor tissue by accelerating DNA damage and producing free radicals.
Hao, Wang, Xiaoyu, Mu, Hua, He, Xiao-Dong, Zhang   +3 more
openaire   +2 more sources

Care with radiosensitizers

The British Journal of Radiology, 1980
I should like to comment on the correspondence between Adams and Dische and Hendry and Sutton in The British Journal of Radiology (1979). These authors were debating the risk of sensitization of normal tissues by misonidazole at the dose levels of radiation and drug that are likely to be used clinically.
openaire   +4 more sources

Antimetabolite Radiosensitizers

Journal of Clinical Oncology, 2007
Radiosensitization with antimetabolites has improved clinical outcome for patients with solid malignancies, especially cancers of the GI tract, cervix, and head and neck. Fluorouracil (FU) and hydroxyurea have been widely used clinically during the last four decades, and promising results have been observed more recently with gemcitabine. Although the
Donna S, Shewach, Theodore S, Lawrence
openaire   +2 more sources

Biophysical radiosensitization

Radiation and Environmental Biophysics, 1983
Experimental studies on normal and tumor-bearing rats revealed that chronic treatment with hydroquinone (5 mg/kg/day) inhibited catalase activity in liver, spleen, blood, and H 18R tumor. 3H-hydroquinone (1.5 microCi/g body weight) showed tumor specificity, with maximum radioactivity in the tumor at 1 h after administration. The biological half-time of
C, Vladescu, M, Apetroae
openaire   +2 more sources