Results 181 to 190 of about 14,471 (229)
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Anti-Cancer Drugs, 2014
In parallel with the discovery of the taxanes, our understanding of the molecular underpinnings that comprise the classic biologic principles of fractionated radiotherapy has rapidly evolved over the past half century. Early studies have implicated DNA as the primary target for radiation-induced lethality.
Encouse B, Golden +2 more
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In parallel with the discovery of the taxanes, our understanding of the molecular underpinnings that comprise the classic biologic principles of fractionated radiotherapy has rapidly evolved over the past half century. Early studies have implicated DNA as the primary target for radiation-induced lethality.
Encouse B, Golden +2 more
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Radiotherapy and Oncology, 2015 Item does not contain fulltextBACKGROUND AND PURPOSE: The PARP inhibitor olaparib is currently tested in clinical phase 1 trials to define safe dose levels in combination with RT. However, certain clinically relevant insights are still lacking.
Rosemarie De Haan, Marcel Verheij
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Parameters of Radiosensitivity
Radiation Research, 1986Dr. B. Fertil, Dr. E. P. Malaise, and co-workers have shown (1-5) that despite wide variability in the shapes of published in vitro survival curves for cells of human origin, there are, on average, systematic differences in the shapes of survival curves in the low-dose region among cells of distinct histological types.
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The British Journal of Radiology, 1979
Hendry and Sutton (1978) express concern about the possible sensitizing effect of misonidazole in normal tissues in patients treated with this drug combined with radiotherapy. Their argument is based upon the enhanced effect seen in human normal tissues following treatment in hyperbaric oxygen and upon observations in animals when radiotherapy is ...
G E, Adams, S, Dische
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Hendry and Sutton (1978) express concern about the possible sensitizing effect of misonidazole in normal tissues in patients treated with this drug combined with radiotherapy. Their argument is based upon the enhanced effect seen in human normal tissues following treatment in hyperbaric oxygen and upon observations in animals when radiotherapy is ...
G E, Adams, S, Dische
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The British Journal of Radiology, 1978
In current radiotherapy trials with the oxygen-mimetic radiosensitizing drugs, which are expected to overcome the potential problem of resistant hypoxic tumour cells, no allowance is being made for sensitization of normal tissue. These new agents are competing with hyperbaric oxygen (HBO) for providing therapeutic benefit, and sensitization by HBO was ...
J H, Hendry, M L, Sutton
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In current radiotherapy trials with the oxygen-mimetic radiosensitizing drugs, which are expected to overcome the potential problem of resistant hypoxic tumour cells, no allowance is being made for sensitization of normal tissue. These new agents are competing with hyperbaric oxygen (HBO) for providing therapeutic benefit, and sensitization by HBO was ...
J H, Hendry, M L, Sutton
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Radioprotection by Radiosensitizers
1977The title to this paper was chosen to point deliberately upon the semantic problem involved in characterizing modifications of the response to radiation. In considering the multitarget single-hit model, cellular sensitivity can be modified in the sense of a change in the energy per lethal event and/or in the sense of a change in the amount of ...
L, Révész, B, Littbrand
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[Radiosensitization by hypoxic cell radiosensitizer--present status of radiosensitizer].
Gan no rinsho. Japan journal of cancer clinics, 1991Because of the unsuccessful clinical trials of misonidazole (MISO), many efforts have been made to find a new hypoxic cell sensitizer which is more effective and/or less toxic than MISO. In Japan, RK-28 is already under going Phase II clinical evaluation and RP-170, KU-2285 and KIH-802 have been proven to be effective both in vitro and in vivo and are ...
C, Murayama, T, Mori
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Radiosensitization and Nanoparticles
2015Nanomaterials have been shown to have physical and chemical properties that have opened new avenues for cancer diagnosis and therapy. Nanoconstructs that enhance existing treatments for cancer, such as radiation therapy, are being explored in several different ways. Two general paths toward nanomaterial-enabled radiosensitization have been explored: (1)
Tatjana, Paunesku +3 more
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Chromosomes, Cancer, and Radiosensitivity
American Journal of Clinical Oncology, 1982Some specific chromosomal abnormalities are associated with certain cancers. The earliest description of such a specific association is the one of the Philadelphia chromosome and myelogenous leukemia (1960). Other congenital karyotype abnormalities are associated with specific cancers. Examples of these are Down's syndrome with leukemia and Klinefelter'
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[Radiosensitizer: hypoxic cell radiosensitizer].
Gan to kagaku ryoho. Cancer & chemotherapy, 1989There is a world-wide demand for a clinically usable sensitizer for radio-resistant hypoxic cells. After unsuccessful clinical trials of misonidazole, many efforts have been made to develop new sensitizers. In the U.S., Brown and others reported a new drug named SR-2508 (ethanidazole), which is now in phase II and III clinical trials.
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