Results 61 to 70 of about 27,469 (292)

HDAC2 Inhibitor Valproic Acid Increases Radiation Sensitivity of Drug-Resistant Melanoma Cells

Medical Sciences, 2019
Resistance to anticancer drugs limits the effectiveness of chemotherapy in cancers. Melanoma cell lines B16F10C and A375C (parental) and B16F10R and A375R (drug-resistant sublines) were used to test radiation sensitization potential of valproic acid (VPA)
Bhuvanesh Sukhlal Kalal, Vinitha Ramanath Pai, Santosh Kumar Behera, Hiriyur Mallaiah Somashekarappa   +3 more
doaj   +1 more source

Ultrasmall Platinum Nanoparticles for Radiation‐Enhanced Cancer Therapy

Advanced Functional Materials, EarlyView.
This work proposes a nanomedicine‐based strategy to enhance X‐ray radiotherapy for cancer treatment. Ultrasmall Pt‐NPs exhibit catalase‐like activity that may contribute to modulation of the tumor microenvironment and amplify interactions between radiation and biological matter, leading to increased DNA damage.
Miguel Encinas‐Gimenez, Jose I. Garcia‐Peiro, Jose L. Hueso, Eduardo Caleiras, Laura Notario, Felipe Hornos, Pilar Martin‐Duque, Antonio De la Vieja, Jesus Santamaria   +8 more
wiley   +1 more source

A new concurrent chemotherapy with vinorelbine and mitomycin C in combination with radiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck [PDF]

, 2005
Objective: The purpose of this pilot study was to evaluate the feasibility and toxicity of concurrent chemotherapy with vinorelbine and mitomycin C in combination with accelerated radiotherapy (RT) in patients with locally advanced cancer of the head and
Bernier J, Budach W, Colevas AD, Colleoni M, Conti F, De Placido S, Degardin M, Dische S, Dobrowsky W, Gasparini G, Gralla R, Grau C, Haffty BG, Harrison LB, Hehr T, Kies MS, Koch WM, Munker R, Pouillart P, Poulsen MG, Regine WF, Shin DM, Siu LL, Vici P, Vokes EE, Wendt TG   +25 more
core   +1 more source

Plasmonic Nanomachines: Creating Local Potential Gradients and Motions

Advanced Materials, EarlyView.
Plasmonic nanomachines can generate optical, thermal, and chemical potential gradients to drive directional rectilinear, rotational, and twisting motions at the nanometer scale. The integration of multimodal plasmonic forces with functional materials and programmed structural distortions enables precise spatiotemporal actuation, thereby providing a ...
Yoonhee Kim, Soohyun Ji, Donghyun Choi, Jwa‐Min Nam   +3 more
wiley   +1 more source

Application of High-Z Nanoparticles to Enhance Current Radiotherapy Treatment

Molecules
Radiotherapy is an essential component of the treatment regimens for many cancer patients. Despite recent technological advancements to improve dose delivery techniques, the dose escalation required to enhance tumor control is limited due to the ...
Nolan Jackson, Daniel Cecchi, Wayne Beckham, Devika B. Chithrani   +3 more
doaj   +1 more source

Radiosensitization in Pediatric High-Grade Glioma: Targets, Resistance and Developments

Frontiers in Oncology, 2021
Pediatric high-grade gliomas (pHGG) are the leading cause of cancer-related death in children. These epigenetically dysregulated tumors often harbor mutations in genes encoding histone 3, which contributes to a stem cell-like, therapy-resistant phenotype.
Dennis S. Metselaar, Dennis S. Metselaar, Aimée du Chatinier, Iris Stuiver, Gertjan J. L. Kaspers, Gertjan J. L. Kaspers, Esther Hulleman   +6 more
doaj   +1 more source

The Histone Deacetylase Inhibitor Romidepsin Spares Normal Tissues While Acting as an Effective Radiosensitizer in Bladder Tumors in Vivo

International Journal of Radiation Oncology, Biology, Physics, 2020
Purpose Muscle-invasive bladder cancer has a 40% to 60% 5-year survival rate with radical treatment by surgical removal of the bladder or radiation therapy–based bladder preservation techniques, including concurrent chemoradiation.
S. Paillas, C. Then, Susan Kilgas, Jia‐Ling Ruan, James R. Thompson, Amy Elliott, S. Smart, A. Kiltie   +7 more
semanticscholar   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Effect of Gold Nanoparticle Radiosensitization on DNA Damage Using a Quartz Tuning Fork Sensor

Micromachines, 2023
The development of sensor technology enables the creation of DNA-based biosensors for biomedical applications. Herein, a quartz tuning fork (QTF) sensing system was employed as a transducer for biomedical applications to address indirect DNA damage ...
Nadyah Alanazi, Reem Alanazi, Mahmoud Algawati, Khaled Alzahrani, Abdullah N. Alodhayb   +4 more
doaj   +1 more source

A new potential radiosensitizer: ammonium persulfate modified WCNTs [PDF]

, 2007
Radiotherapy plays a very important role in cancer treatment. Radiosensitizers have been widely used to enhance the radiosensitivity of cancer cells at given radiations.
Bo-Zhang Yu, Jian-She Yang, Wen-Xin Li
core   +1 more source