Results 221 to 230 of about 10,067 (250)
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The radiosynthesis of [-methyl-11C]-sertraline
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, 1989[N-methyl-11C]Sertraline, a potential agent for the study of the serotonergic system in vivo with positron emission tomography, was prepared by N-methylation of the corresponding norcompound with [11C]iodomethane, which was itself prepared from cyclotron-produced [11C]carbon dioxide.
M C, Lasne, V W, Pike, D R, Turton
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Rapid and reproducible radiosynthesis of [18F] FHBG
Nuclear Medicine and Biology, 20049-(4-[18F] Fluoro-3-hydroxymethylbutyl) guanine ([18F] FHBG), an imaging agent for gene therapy using PET, was prepared in a one-pot, two-step synthesis. Microwave (MW) mediated nucleophilic fluorination of N2, monomethoxytrityl-9-[4-(tosyl)-3-monomethoxytrityl-methylbutyl] guanine using no-carrier-added [18F] fluoride, followed by deprotection with ...
Datta E, Ponde +3 more
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Radiosynthesis of NCA [carbonyl-11C]6-fluoromelatonin
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, 1988A method is described for the preparation of [carbonyl-11C]6-fluoromelatonin for intravenous injection and potential study of the melatonin system in vivo by positron emission tomography. The preparation is based on the acetylation of 6-fluoro-5-methoxytryptamine with NCA [1-11C]acetyl chloride (itself prepared from cyclotron-produced [11C]carbon ...
D, Le Bars +3 more
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The automated radiosynthesis of [18F]FP-TZTP
Nuclear Medicine and Biology, 2003[(18)F]FP-TZTP (3-(3-(3-[(18)F]fluoropropylthio)-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine) is a muscarinic ligand that displays in vivo selectivity for the M2 subtype. We have developed a one-step radiosynthesis of [(18)F]FP-TZTP that can be conducted with an automated synthesis unit. A number of hardware and software modifications to
Dale O, Kiesewetter +2 more
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Radiosynthesis of 6-[C-11]-d-glucose
Applied Radiation and Isotopes, 1993Availability of 6-[C-11]-D-glucose will permit positron emission tomography (PET) investigations of glucose utilization derived from the pentose shunt which supports biosynthesis in tissues. The first radiosynthesis of 6-[C-11]-D-glucose is described.
J R, Grierson +3 more
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Gamma-ray radiosynthesis of ozone from air
The International Journal of Applied Radiation and Isotopes, 1966Abstract Ozone concentrations were measured in static and flowing systems of air during γ-irradiation in Mark II Research Irradiator. In a flowing system, the concentration of ozone varied from 1.68 to 1.74 ppm over a dose range 50—1000 krad; the G values were about 11. In a static system the concentration varied from 7.36 ppm to 58.09 ppm, depending
J, Shah, E C, Maxie
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Radiosynthesis of Dextroamphetamine-14C Sulfate
Journal of Pharmaceutical Sciences, 1965A high yield radiosynthesis of dl -amphetamine-7- 14 C was developed using 0.5 c. of benzoic-7- 14 C acid as the starting material. The dl -amphetamine-7 14 C was resolved in 84 per cent yields by the successive crystallization of d -amphetamine- 14 C d -bitartrate and l -amphetamine- 14 C l -bitartrate salts.
Dale Blackburn, Garth Burghard
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Positron Emission Tomography Radiosynthesis in Microreactors
Journal of Flow Chemistry, 2012Positron emission tomography (PET) is a very powerful diagnostic technique routinely used in a variety of medical applications. This review article summarises the developments of using microreactor technology for the radiochemical synthesis of PETagents. The advantages of manufacturing these imaging drugs using microreactors are described, and a review
Paul Watts +2 more
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Improved radiosynthesis of 2-[123I]iodomelatonin
Applied Radiation and Isotopes, 1994Abstract An improved method for the radiosynthesis of [ 123 I]melatonin is presented. The suitability of several oxidizing agents, such as Iodo-Gen, chloramine-T, hydrogen peroxide and in situ generated peracetic acid were evaluated for the oxidative radioiodination reactions.
D. Du T. Rossouw, J.H. Langenhoven
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Radiosynthesis of [18F]-fluorobenzoate-doxorubicin Using Acylation Approach
Current Radiopharmaceuticals, 2016Previously, we have labeled doxorubicin with [99Tc] and evaluated its potential as a SPECT agent to detect cancer in tumor bearing mice. In this study, we sought to radiolabel doxorubicin with [18F] using acylation method.A quaternary salt of the precursor pentamethylbenzyl-4-(trimethylammonium trifluoromethanesulfonate) benzoate was synthesized and ...
Pardeep, Kumar +6 more
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