Results 231 to 240 of about 10,067 (250)

Solid Phase Reagents in Radiosynthesis

1995
Radiochemists rely heavily upon functionalized polymers and chromatographic supports for rapid isolation of radiochemicals and labeled intermediates. Extending the use of solid phase reagents from separation steps to radiolabeling reactions and organic transformations has many potential benefits; solid phase methods can shorten overall synthesis times,
G. Keith Mulholland, Douglas M. Jewett
openaire   +1 more source

Radiosynthesis of [14C]acarbose.

Arzneimittel-Forschung, 1990
Acarbose (O-4,6-dideoxy-4-[[(1S, 4R, 5S, 6S)-4,5,6-trihydroxy-3- (hydroxymethyl)-2-cyclohexen-1-yl]amino]-a-D-glucopyranosyl-(1---- 4)-O-a-D- glucopyranosyl-(1----4)-4-glucopyranose, Bay g 5421), an a-glucosidase inhibitor from Actinoplanes, has been developed for the treatment of diabetes mellitus.
W, Maul, L, Müller, J, Pfitzner, E, Rauenbusch, H, Schutt   +4 more
openaire   +1 more source

Microfluidic reactor for the radiosynthesis of PET radiotracers

Applied Radiation and Isotopes, 2006
Here we show the first application of a microfabricated reaction system to PET radiochemistry, we term "microfluidic PET". The short half-life of the positron emitting isotopes and the trace chemical quantities used in radiolabelling make PET radiochemistry amenable to miniaturisation.
J M, Gillies, C, Prenant, G N, Chimon, G J, Smethurst, W, Perrie, I, Hamblett, B, Dekker, J, Zweit   +7 more
openaire   +2 more sources

Radiosynthesis of [¹¹C]paclitaxel

Journal of Labelled Compounds and Radiopharmaceuticals, 2002
Abstract[11C]paclitaxel, a potential solid tumor imaging agent, was synthesized by reacting [α‐11C]benzoyl chloride with the primary amine precursor of paclitaxel. The time for synthesis, purification, and formulation was 38 min from end of bombardment with an average specific radioactivity of 49.9 GBq/μmol (1349 mCi/μmol) at end of synthesis.
Hayden T. Ravert, Raymond W. Klecker, Jerry M. Collins, William B. Mathews, Martin G. Pomper, Richard L. Wahl, Robert F. Dannals   +6 more
openaire   +1 more source

Radiosynthesis of new radio neurotensin (8-13) analogues

Journal of Labelled Compounds and Radiopharmaceuticals, 1998
Two types of radiolabelled neurotensin(8-13) analogues have been synthesised. For radioiodination-2- and 4-bromophenyl-acetyl and 2- and 4-bromobenzoyl Arg 8 substituted neurotensin(8-13) were used as substrates for radiolabelling carried out by the Cu 1+ assisted non-isotopic nucleophilic exchange with a labelling yield ranging from 55 to 85 ...
Terriere, Dirk, Chavatte, Kris, Ceusters, M., Tourwe, Dirk, Mertens, John   +4 more
openaire   +2 more sources

Radiosynthesis of [¹¹C]docetaxel

Journal of Labelled Compounds and Radiopharmaceuticals, 2004
AbstractDocetaxel (Taxotere®) is an accepted chemotherapeutic agent for the treatment of breast cancer and non‐small cell lung cancers. A potential means of predicting response is measuring tumor uptake of [11C]docetaxel using Positron Emission Tomography (PET).
Van Tilburg, E. W., Franssen, E. J.F., Van Der Hoeven, J. J.M., Van Der Meij, M., Elshove, D., Lammertsma, A. A., Windhorst, A. D.   +6 more
openaire   +2 more sources

Solid-phase radiosynthesis of [11C]WAY 100635

Journal of Labelled Compounds and Radiopharmaceuticals, 1996
An efficient, fast and simple method is described for the radiosynthesis of the potent and selective 5-HT 1A antagonist [O-methyl- 11 C]-N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexane carboxamide ([ 11 C]WAY 100635). [ 11 C]Iodomethane was effectively trapped on a C 18 reverse-phase cartridge at ambient temperature where it
Alan A. Wilson, Jean N. DaSilva, Sylvain Houle   +2 more
openaire   +1 more source

[¹⁸F]Fluoropyruvate: radiosynthesis and initial biological evaluation

Journal of Labelled Compounds and Radiopharmaceuticals, 2014
The radiosynthesis of [18F]fluoropyruvate was investigated using numerous precursors were synthesized from ethyl 2,2‐diethoxy‐3‐hydroxypropanoate (5) containing different leaving groups: mesylate, tosylate, triflate, and nonaflate. These precursors were evaluated for [18F]fluoride incorporation with triflate being superior.
Keith, Graham, Andre, Müller, Lutz, Lehmann, Norman, Koglin, Ludger, Dinkelborg, Holger, Siebeneicher   +5 more
openaire   +2 more sources

Synthesis, Radiosynthesis and Metabolism of 131I-Y-c(CGRRAGGSC)

Anti-Cancer Agents in Medicinal Chemistry, 2018
The formation of the complex interleukin-11(IL-11) and IL-11 receptor (IL-11R) is closely related with tumor progression. Binding of IL-11 to the IL-11 receptor α-chain (IL-11Rα) has been suggested as a target for human cancer. The cyclic peptide c(CGRRAGGSC) is a mimic of IL-11.To explore 131I-Y-c(CGRRAGGSC) synthesis and radiosynthesis, and ...
Jilai, Xie, Donghui, Pan, Mudan, Lu, Xuan, Chen, Yu, Chen, Ting, Zhang, Yan, Xie, Huan, Zhou, Lu, Liu, Min, Yang, Jiajun, Wang, Daozhen, Chen   +11 more
openaire   +2 more sources

A radiosynthesis of fluorine-18 fluoromisonidazole.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1989
A new preparation of [18F]fluoromisonidazole [1H-1-(3-[18F] fluoro-2-hydroxypropyl)-2-nitroimidazole] is presented as a two-step, two-pot reaction sequence. The method is useful for the production of 20-30 mCi quantities of this compound from [18F]fluoride, available in 40% radiochemical yield at end of bombardment (EOB) with a specific activity (nca ...
J R, Grierson, J M, Link, C A, Mathis, J S, Rasey, K A, Krohn   +4 more
openaire   +1 more source