Results 81 to 90 of about 128,967 (306)

Scintillating fiber devices for particle therapy applications [PDF]

, 2018
Particle Therapy (PT) is a radiation therapy technique in which solid tumors are treated with charged ions and exploits the achievable highly localized dose delivery, allowing to spare healthy tissues and organs at risk.
Battistoni, G., Camillocci, E. Solfaroli, De Simoni, M., Dong, Y., Embriaco, A., Fischetti, M., Giacometti, V., Gioscio, E., Magi, M., Mancini-Terracciano, C., Marafini, M., Mattei, I., Mirabelli, R., Muraro, S., Patera, V., Sarti, A., Sciubba, A., Toppi, M., Traini, G., Valle, S. M.   +19 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Development of Physics Applied to Medicine in the UK, 1945–90 [PDF]

, 2006
Annotated and edited transcript of a Witness Seminar held on 5 July 2005. Introduction by Dr Jeff Hughes.First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2006.©The Trustee of the Wellcome Trust, London, 2006.All volumes ...
Christie, DA, Tansey, EM
core  

LabVIEW-based control and acquisition system for the dosimetric characterization of a silicon strip detector [PDF]

, 2017
Theaimofthisworkistopresentanewdataacquisition,control,andanalysissoftwaresystemwrittenin LabVIEW.Thissystemhasbeendesignedtoobtainthedosimetryofasiliconstripdetectorinpolyethylene.
Arráns, Rafael, Cortés Giraldo, Miguel Antonio, Espino Navas, José Manuel, Gallardo Fuentes, María Isabel, Ovejero Benito, M. C., Perez Vega-Leal, Alfredo, Selva, A.   +6 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Dosimetric characterization of the laser-accelerated high-energy electron beam for radiotherapy applications

Physical Review Accelerators and Beams
Radiotherapy utilizing very-high-energy electron (VHEE) beams in the range of 50–300 MeV has gained significant interest over the past two decades due to their advantageous dose characteristics, deep tissue penetration capabilities, and potential for ...
Bing Zhou, Zhiyuan Guo, Shuang Liu, Yang Wan, Junqi Liu, Haiyang Wang, Yifei Pi, Bo Guo, Jianfei Hua, Wei Lu   +9 more
doaj   +1 more source

Impact of Metallic Implants on Dose Distribution in Radiotherapy with Electrons, Photons, Protons, and Very-High-Energy Beams

Applied Sciences
Metallic implants in radiotherapy patients alter dose distributions due to their high density and unique composition, potentially compromising treatment precision.
Nicole Kmec Bedri, Milan Smetana, Ladislav Janousek   +2 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Compact dose delivery of laser-accelerated high-energy electron beams toward radiotherapy applications

Physical Review Accelerators and Beams
The use of very high-energy electron (VHEE) beams for radiotherapy has been actively studied for over two decades due to their advantageous dose distribution, deep penetration depth, and great potential of ultrahigh dose-rate irradiation. Recently, laser-
Bing Zhou, Zhiyuan Guo, Yang Wan, Shuang Liu, Bo Peng, Jianfei Hua, Wei Lu   +6 more
doaj   +1 more source

Radiotherapy for Rectal Cancer and Radiation-Induced Malignancies from Epidemiological and Dosimetric Data

Applied Sciences
Preoperative or postoperative radiation therapy is broadly employed in patients with rectal carcinoma. Radiotherapy directs high-energy beams of ionizing radiation toward the tumor area to destroy cancer cells.
Stefanos Kachris, Michalis Mazonakis
doaj   +1 more source