Results 91 to 100 of about 1,093,427 (365)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Ultra-high dose-rate (≥100 Gy⋅s−1) irradiation, termed FLASH radiotherapy, affords some remarkable (if not unexpected) normal tissue sparing in the irradiated brain when compared with conventional dose rates (0.07–0.1 Gy⋅s−1) used in ...
Pierre Montay-Gruel, M. Acharya, K. Petersson, L. Alikhani, Chakradhar Yakkala, B. Allen, J. Ollivier, B. Petit, P. G. Jorge, Amber R. Syage, Thuan A. Nguyen, A. A. Baddour, Celine Lu, P. Singh, R. Moeckli, F. Bochud, J. Germond, P. Froidevaux, C. Bailat, J. Bourhis, M. Vozenin, C. Limoli   +21 more
semanticscholar   +1 more source

Hypofractionated stereotactic radiotherapy for brain metastases in lung cancer patients: dose‒response effect and toxicity

Discover Oncology
Background Lung cancer is a common cause of brain metastases, approximately 40% of patients with lung cancer will develop brain metastases at some point during their disease.
Kaicheng Pan, Bing Wang, Xiao Xu, Jiafeng Liang, Yi Tang, Shenglin Ma, Bing Xia, Lucheng Zhu   +7 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Prognosis of acute coronary syndromes after radiotherapy for breast cancer [PDF]

, 2020
Background and purpose: Breast cancer patients treated with radiotherapy are at increased risk of subsequent acute coronary syndromes (ACS). We aimed to study if radiotherapy also influences the prognosis of these ACS.
Schaapveld, M. (Michael), Buddeke, J., Boekel, N.B., Seynaeve, C.M. (Caroline), Vaartjes, I. (Ilonca), Jacobse, JN, Schaapveld, M, Hooning, Maartje, Aleman, BM, Sonke, GS, van Leeuwen, FE, Rutgers, EJ, Baaijens, M. (Margreet), Vaartjes, I, Baaijens, Margreet, Russell, NS, Russell, N.S. (Nicola), Aleman, B.M., Jacobse, J.N., Buddeke, J, Seynaeve, Caroline, Boekel, NB, Maas, A. (Arne), Maas, A, Boekel, LY, Boekel, L.Y., Leeuwen, F.E. (Flora) van, Hooning, M.J. (Maartje)   +27 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Previous radiotherapy and the clinical activity and toxicity of pembrolizumab in the treatment of non-small-cell lung cancer: a secondary analysis of the KEYNOTE-001 phase 1 trial

The Lancet Oncology, 2017
Summary Background Preclinical studies have found radiotherapy enhances antitumour immune responses. We aimed to assess disease control and pulmonary toxicity in patients who previously received radiotherapy for non-small-cell lung cancer (NSCLC) before ...
N. Shaverdian, A. Lisberg, K. Bornazyan, D. Veruttipong, J. Goldman, S. Formenti, E. Garon, Percy Lee   +7 more
semanticscholar   +1 more source

From IB2 to IIIB locally advanced cervical cancers: report of a ten-year experience

Radiation Oncology, 2018
Background Despite screening campaigns, cervical cancers remain among the most prevalent malignancies and carry significant mortality, especially in developing countries. Most studies report outcomes of patients receiving the usual standard of care.
Sophie Espenel, Max-Adrien Garcia, Jane-Chloé Trone, Elodie Guillaume, Annabelle Harris, Amel Rehailia-Blanchard, Ming Yuan He, Sarra Ouni, Alexis Vallard, Chloé Rancoule, Majed Ben Mrad, Céline Chauleur, Guy De Laroche, Jean-Baptiste Guy, Pablo Moreno-Acosta, Nicolas Magné   +15 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Correction to: From IB2 to IIIB locally advanced cervical cancers: report of a ten-year experience

Radiation Oncology, 2018
In the original publication [1] one author name was spelled incorrect.
Sophie Espenel, Max-Adrien Garcia, Jane-Chloé Trone, Elodie Guillaume, Annabelle Harris, Amel Rehailia-Blanchard, Ming Yuan He, Sarra Ouni, Alexis Vallard, Chloé Rancoule, Majed Ben Mrad, Céline Chauleur, Guy De Laroche, Jean-Baptiste Guy, Pablo Moreno-Acosta, Nicolas Magné   +15 more
doaj   +1 more source